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  • merck millipore,默克密理博,AB5186-50UL,Anti-Potassium Channel Kv2.1 Antibody

  • merck millipore,默克密理博,AB5186-50UL,Anti-Potassium Channel Kv2.1 Antibody

    产品名称：Anti-Potassium Channel Kv2.1 Antibody
    产品型号：AB5186-50UL
    Anti-Potassium Channel Kv2.1 Antibody detects level of Potassium Channel Kv2.1 & has been published & validated for use in IH & WB. Less<<

    merck millipore,默克密理博,AB5186-50UL,Anti-Potassium Channel Kv2.1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5186-50UL,Anti-Potassium Channel Kv2.1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWB, IHCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5186-50UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Potassium Channel Kv2.1 Antibody
    产品信息
    格式 Purified
    控制
    • CONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen (lyophilized powder in phosphate buffered saline, pH 7.4, containing 5% sucrose and 0.025% sodium azide). The stock solution of the antigen can be made up using 50 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
    演示 Purified immunoglobulin by Protein A. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
    应用
    应用 Anti-Potassium Channel Kv2.1 Antibody detects level of Potassium Channel Kv2.1 & has been published & validated for use in IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western blot: 1:250-1:500 using ECL on rat brain membranes.

    Immunohistochemistry using rat brain sections.

    Dilutions should be made using a carrier protein such as BSA (1-3%)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Purified peptide from rat Kv2.1 (amino acids 841-857) (Accession P15387),
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes a full length Kv2.1 protein. Does not cross react with any other potassium channel antigens tested so far.

    SPECIES REACTIVITIES: Should work in mouse (100% epitope homology) and in human and rabbit (88% epitope homology). Other species have not been tested.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_004975.2
    Entrez基因汇总 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.
    基因符号
    • DRK1
    • KCNB1
    • KV2.1
    • h-DRK1
    • Kv2.1
    UniProt编号
    • Q14721
    UniProt汇总 FUNCTION: SwissProt: Q14721 # Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
    SIZE: 858 amino acids; 95878 Da
    SUBUNIT: Heteromultimer with KCNG2, KCNG3, KCNG4, KCNS1, KCNS2, KCNS3 and KCNV2 (By similarity).
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    DOMAIN: SwissProt: Q14721 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. & The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    PTM: Phosphorylated on serine residues in the C-terminal cytoplasmic tail (By similarity).
    SIMILARITY: Belongs to the potassium channel family. B (Shab) subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5186-50UL,Anti-Potassium Channel Kv2.1 Antibody

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