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品种反应性 主要应用 宿主 格式 抗体类型 F, H, B, Rb, Po, Sh, Gp, Ch IH(P) M Unpurified Monoclonal Antibody 描述 产品目录编号 05-1107 Replaces MAB10218 描述 Anti-Insulin Antibody, clone CE9H9 背景信息 Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism. 产品信息 格式 Unpurified 控制 - Human pancreas tissue.
演示 Unpurified mouse monoclonal as liquid ascites fluid containing no preservatives. 应用 应用 Detect Insulin using this Anti-Insulin Antibody, clone CE9H9 validated for use in IH(P). 主要应用 - Immunohistochemistry (Paraffin)
生物信息 免疫原品种 Zinc containing crystalline human insulin 克隆 CE9H9 宿主 Mouse 特异性 The antibody binds to insulin from human, cow, pig and rabbit and to pro-insulin from cow and pig. 同种型 IgG1 品种反应性 FishHumanBovineRabbitPigSheepGuinea PigChicken Species Reactivity Note Proven to react with human, bovine, pig, rabbit, sheep and guinea pig. 抗体类型 Monoclonal Antibody Entrez基因编号 - P01308
基因符号 - proinsulin
- ILPR
- IRDN
- OTTHUMP00000011161
- OTTHUMP00000011162
- OTTHUMP00000196038
- insulin
纯化方法 Unpurified ascites UniProt编号 - P01308
UniProt汇总 FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SUBUNIT STRUCTURE: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
INVOLVEMENT IN DISEASE: Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
PHARMACEUTICAL USE: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.
SEQUENCE SIMILARITIES: Belongs to the insulin family.
SEQUENCE CAUTION: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.产品使用声明 质量保证 Evaluated by Immunohistochemistry in human pancreas tissue.
IHC Analysis: A 1.25 µg/mL dilution of this antibody detected insulin in human pancreas tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C from date of receipt 包装信息 数量 100 µL
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