merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5178-50UL,Anti-Potassium Channel Kv1.3 Antibody

  • merck millipore,默克密理博,AB5178-50UL,Anti-Potassium Channel Kv1.3 Antibody

    产品名称：Anti-Potassium Channel Kv1.3 Antibody
    产品型号：AB5178-50UL
    Anti-Potassium Channel Kv1.3 Antibody detects level of Potassium Channel Kv1.3 & has been published & validated for use in IH & WB.

    merck millipore,默克密理博,AB5178-50UL,Anti-Potassium Channel Kv1.3 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5178-50UL,Anti-Potassium Channel Kv1.3 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWB, IHCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5178-50UL
    Replaces AB9784
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Potassium Channel Kv1.3 Antibody
    产品信息
    格式 Purified
    控制
    • Included free of charge with the antibody is 120 µg of control antigen. The stock solution of the antigen can be made up using 100 μL of PBS. For positive control, in Western blot using 20 ng of protein per minigel lane. For negative control, preincubate 3 μg of fusion protein with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
    演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
    应用
    应用 Anti-Potassium Channel Kv1.3 Antibody detects level of Potassium Channel Kv1.3 & has been published & validated for use in IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry on rat brain sections.

    Western blot: 1:200 using ECL on rat brain membranes.

    Dilutions should be made using a carrier protein such as BSA (1-3%)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 GST fusion protein and a C-terminal portion of human Kv1.3 protein (amino acids 471-523) (Accession P22001).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes a full length Kv1.3 protein. Does not cross react with any other potassium channel antigens tested so far.
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002232.3
    Entrez基因汇总 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
    基因符号
    • PCN3
    • KCNA3
    • HLK3
    • HGK5
    • KV1.3
    • HuKIII
    • HPCN3
    • Kv1.3
    • MK3
    • HUKIII
    UniProt编号
    • P22001
    UniProt汇总 FUNCTION: SwissProt: P22001 # Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
    SIZE: 523 amino acids; 58304 Da
    SUBUNIT: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    DOMAIN: SwissProt: P22001 The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. & The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    SIMILARITY: Belongs to the potassium channel family. A (Shaker) subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5178-50UL,Anti-Potassium Channel Kv1.3 Antibody

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