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merck millipore,默克密理博,AB1787P,Anti-Dopamine D4 Receptor Antibody, extracellular domain
产品名称：Anti-Dopamine D4 Receptor Antibody, extracellular domain
产品型号：AB1787P
Anti-Dopamine D4 Receptor Antibody, extracellular domain is an antibody against Dopamine D4 Receptor for use in ELISA & WB.
merck millipore,默克密理博,AB1787P,Anti-Dopamine D4 Receptor Antibody, extracellular domain
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB1787P Replaces AB1789P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Dopamine D4 Receptor Antibody, extracellular domain 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in PBS with 0.1% BSA 应用 应用 Anti-Dopamine D4 Receptor Antibody, extracellular domain is an antibody against Dopamine D4 Receptor for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-10 μg/mL (Chemiluminescence technique). Approximately 100-400 μg of membrane protein/lane should be loaded to visualize the receptor band. Antibody detects ~55kDa band in HT222 cells and mouse hippocampal membranes. {, Ishige, K et.al.(2001) J. Neuroscience 21(16):6069-6076.
ELISA: 0.5-1.0 μg/mL (1 μg/mL immunogen peptide/well)
Not tested in immunohistochemical methods.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A 10 amino acid peptide sequence from the mouse D4 receptor within the 3rd extracellular domain. 表位 extracellular domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Specific for Dopamine Receptor D4. Mouse Dopamine receptor D4 is a 387 aa, G-protein coupled and transmembrane receptor protein (Van Tol et al. 1992; Legerski & Peterson 1992; Livingstone et al. 1992; Seeman et al. 1994). The immunogen peptide shows no significant homology with other dopamine receptors (D1, D2, D3 or D5).
SPECIES REACTIVITIES: The immunogen peptide shows sequence homology of 90% with rat and human D4 receptors (Van Tol et al. 1992; Legerski & Peterson 1992; Livingstone et al. 1992; Seeman et al. 1994; O'Malley et al. 1992). Antibody cross-reactivity with D4R from various species is not known.品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000797.2
Entrez基因汇总 This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. 基因符号 - D
- DRD4
- D4DR
UniProt编号 - P21917
UniProt汇总 FUNCTION: SwissProt: P21917 # This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
SIZE: 467 amino acids; 48361 Da
SUBUNIT: Interacts with CLIC6 (By similarity) and GPRASP1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P21917 ## Belongs to the G-protein coupled receptor 1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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