merck millipore,默克密理愽
  • merck millipore,默克密理博,AB4250,Anti-CXC Chemokine Receptor 3 Antibody, CT domain

  • merck millipore,默克密理博,AB4250,Anti-CXC Chemokine Receptor 3 Antibody, CT domain

    产品名称：Anti-CXC Chemokine Receptor 3 Antibody, CT domain
    产品型号：AB4250
    Anti-CXC Chemokine Receptor 3 Antibody, C-terminal domain detects level of CXC Chemokine Receptor 3 & has been published & validated for use in IH(P).

    merck millipore,默克密理博,AB4250,Anti-CXC Chemokine Receptor 3 Antibody, CT domain

  • 产品介绍
  • merck millipore,默克密理博,AB4250,Anti-CXC Chemokine Receptor 3 Antibody, CT domain

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIH(P)RbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB4250
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-CXC Chemokine Receptor 3 Antibody, CT domain
    Alternate Names
    • CXCR3
    背景信息 CXCR3, a chemokine receptor, is highly similar to the interleukin 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS. CXCR3 has been suggested to be the principal inflammatory chemokine receptor involved in intrathecal accumulation of T-cells in multiple sclerosis and diabetes. It is expressed on malignant B cells in chronic lymphoproliferative disorders (Jones et al., 2000). An alternatively spliced isoform, CXCR3B, has recently been identified (Lasagni et al., 2003). CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseases including atherosclerosis, Alzheimer's, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.
    产品信息
    格式 Affinity Purified
    演示 Peptide-affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide
    应用
    应用 Anti-CXC Chemokine Receptor 3 Antibody, C-terminal domain detects level of CXC Chemokine Receptor 3 & has been published & validated for use in IH(P).
    主要应用
    • Immunohistochemistry (Paraffin)
    应用说明 Immunohistochemistry (formalin-fixed paraffin-embedded tissues)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to a sequence within the C-terminal domain of human CXCR3. The immunogen has 82% homology with rat and mouse.
    表位 C-terminal domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes human CXCR3. The specificity of this antibody has been evaluated by IHC staining of human tonsil.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001504.1
    Entrez基因汇总 CD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Historically, CD183 is the third CXC chemokine receptor discovered and, therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells. Therefore, CD183 is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases.
    基因符号
    • MigR
    • CXCR3
    • CD182
    • CXC-R3
    • IP10-R
    • IP10
    • Mig-R
    • CD183
    • CKR-L2
    • CMKAR3
    • GPR9
    • CXCR-3
    UniProt编号
    • P49682
    UniProt汇总 FUNCTION: SwissProt: P49682 # Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Isoform 2 may play a role in angiogenesis. Isoform 3 mediates activity of CXCL11.
    SIZE: 368 amino acids; 40660 Da
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.
    SIMILARITY: SwissProt: P49682 ## Belongs to the G-protein coupled receptor 1 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB4250,Anti-CXC Chemokine Receptor 3 Antibody, CT domain

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