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merck millipore,默克密理博,ABD10,Anti-MSX1 (Msh homeobox 1-like protein) Antibody
产品名称：Anti-MSX1 (Msh homeobox 1-like protein) Antibody
产品型号：ABD10
Anti-MSX1 (Msh homeobox 1-like protein) Antibody detects level of MSX1 (Msh homeobox 1-like protein) & has been published & validated for use in WB.
merck millipore,默克密理博,ABD10,Anti-MSX1 (Msh homeobox 1-like protein) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD10 描述 Anti-MSX1 (Msh homeobox 1-like protein) Antibody Alternate Names - Msh homeobox 1-like protein
- Homeobox protein MSX-1
- Homeobox protein Hox-7
背景信息 The Msx genes are a family of homeobox genes related to the Drosophila msh (muscle segment homeobox)-like gene family. It may play a role in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations associated with MSX1 are tooth agenesis selective type 1, Witkop syndrome, and cleft lip. 产品信息 格式 Affinity Purified 控制 - Human fetal skeletal muscle tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-MSX1 (Msh homeobox 1-like protein) Antibody detects level of MSX1 (Msh homeobox 1-like protein) & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Linear peptide corresponding to human MSX1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002439
Entrez基因汇总 This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq]. 基因符号 - HOX7
- MSX1
纯化方法 Affinity purified UniProt编号 - P28360
UniProt汇总 FUNCTION: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICTY: Expressed in the developing nail bed mesenchyme.
PTM: Sumoylated by PIAS1, desumoylated by SENP1 (By similarity).
INVOLVEMENT IN DISEASE: Defects in MSX1 are the cause of tooth agenesis selective type 1 (STHAG1) [MIM:106600]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Tooth agenesis selective type 1 can be associated with orofacial cleft in some patients.
Note=MSX1 is deleted in some patients with Wolf-Hirschhorn syndrome (WHS). WHS results from sub-telomeric deletions in the short arm of chromosome 4.
Defects in MSX1 are the cause of Witkop syndrome (WITS) [MIM:189500]. WITS is a form of ectodermal dyslasia also called tooth-and-nail syndrome or dysplasia of nails with hypodontia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. Witkop syndrome is characterized by abnormalities largely limited largely to teeth (some of which are missing) and nails (which are poorly formed early in life, especially toenails). This condition is distinguished from anhidrotic ectodermal dysplasia by autosomal dominant inheritance and little involvement of hair and sweat glands. The teeth are not as severely affected.
Defects in MSX1 are the cause of non-syndromic orofacial cleft type 5 (OFC5) [MIM:608874]; also called non-syndromic cleft lip with or without cleft palate 5. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
SEQUENCE SIMILARITIES: Belongs to the Msh homeobox family.
Contains 1 homeobox DNA-binding domain.
SEQUENCE CAUTION: The sequence AAH21285.4 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected MSX1 on 10 µg of human fetal skeletal muscle tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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