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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3743 描述 Anti-OSTERIX;100 µg Antibody Alternate Names - Zinc finger protein osterix
- Sp7 transcription factor
背景信息 OSTERIX, or SP7, is a zinc finger-containing, osteoblast-specific transcription factor that is distinctly expressed in all developing bones, and is a key requirement for the differentiation of pre-osteoblasts into fully functional osteoblasts. While research on the actual functional mechanisms of OSTERIX is still on-going, current findings indicate that OSTERIX expression is induced by BMP-2 and Dlx5, and operates downstream of RUNX2, supporting its role in mesenchymal stem cell differentiation. Further studies also indicate that the OSTERIX transcription factor may also play a role in negatively regulating the Wnt/β-catenin signaling pathways and the proliferation of osteroblast cell types during embryonic osteogenesis. 产品信息 格式 Affinity Purified 控制 - Y79 lysates.
演示 Purified rabbit polyclonal in buffer containing PBS with 0.09% sodium azide. 应用 应用 Detect OSTERIX using this Anti-OSTERIX, 100 µg Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Western Blotting:
Recommended working dilutions are 1:1000.生物信息 免疫原品种 Synthetic human OSTERIX peptide, a.a. 412-427. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptided selected from human OSTERIX 品种反应性 Human Species Reactivity Note Reacts with human. Comparison of sequence homology suggests that this antibody may also react with mouse, rat, equine, and bovine; however, reactivity with other species has not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_152860.1
Entrez基因汇总 SP7 is a C2H2-type zinc finger transcription factor of the SP gene family and a putative master regulator of bone cell differentiation (Gao et al., 2004 [PubMed 15474293]).[supplied by OMIM]
基因符号 - osterix
- MGC126598
- OSX
纯化方法 Peptide affinity purified UniProt编号 - Q8TDD2
UniProt汇总 FUNCTION: Transcriptional activator essential for osteoblast differentiation. Binds to Sp1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).
LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.
产品使用声明 质量保证 Routinely evaluated by Western blot on Y79 lysates. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles. 包装信息 数量 100 µg
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