merck millipore,默克密理博,MABE204,Anti-HoxB4 Antibody, clone EP1919Y, rabbit monoclonal

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merck millipore,默克密理博,MABE204,Anti-HoxB4 Antibody, clone EP1919Y, rabbit monoclonal
产品名称：Anti-HoxB4 Antibody, clone EP1919Y, rabbit monoclonal
产品型号：MABE204
Use Anti-HoxB4 Antibody, clone EP1919Y (Rabbit Monoclonal Antibody) validated in WB, ICC, FC, IP, IHC to detect HoxB4 also known as homeobox B4, Homeobox protein Hox-2.6.

merck millipore,默克密理博,MABE204,Anti-HoxB4 Antibody, clone EP1919Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABE204,Anti-HoxB4 Antibody, clone EP1919Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB, ICC, FC	Rb	Diluted Culture Supernatant	Monoclonal Antibody

描述
产品目录编号	MABE204
描述	Anti-HoxB4 Antibody, clone EP1919Y, rabbit monoclonal
Alternate Names	homeo box 2F homeobox B4 homeo box B4 Homeobox protein Hox-2.6 Homeobox protein Hox-2F homeobox protein Hox-B4
背景信息	Homebox transcription factors (Hox) are encoded by highly conserved developmental genes that are involved embryonic and early hematopoietic development. Specifically, Homeobox B4 (HoxB4) is a transcription factor encoded by HOXB4 gene and it is involved in the developmental regulation of specific positional identities on the anterior-posterior axis of cells. Like all members of HOX family, HoXB4 is abundantly expressed in primitive hematopoietic stem cell (HSC), but then decline with lineage-specific terminal differentiation (1). In HSC, stem cell self-renewal activity is regulated by USF1/2 binding to HoxB4, where binding possibly favors stem cell self-renewal instead of cell differentiation. Jun-B and Fra-1 has been linked as key mediators during cell proliferation and differentiation induced by HoxB4, which leads to increase expression of Cyclin D1 and G1 shortening (2).

产品信息
格式	Diluted Culture Supernatant
控制	K562 cell lysate
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Use Anti-HoxB4 Antibody, clone EP1919Y (Rabbit Monoclonal Antibody) validated in WB, ICC, FC, IP, IHC to detect HoxB4 also known as homeobox B4, Homeobox protein Hox-2.6.
主要应用	Immunohistochemistry Western Blotting Immunocytochemistry Flow Cytometry
应用说明	Immunocytochemistry Analysis: 1:100-1:250 dilution from a representative lot was used in IC. Immunoprecipitation Analysis: 1:40 dilution from a representative lot was used in IP. Flow Cytometry Analysis: 1:20 dilution from a representative lot was used in FC. Immunohistochemistry Analysis: 1:100-1:250 dilution from a representative lot detected HoxB4 in human placenta tissue.

生物信息
免疫原品种	Synthetic peptide corresponding to the middle region of human HoxB4.
表位	Middle region
克隆	EP1919Y
宿主	Rabbit
特异性	This antibody recognizes the middle region of HoxB4.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Demonstrated to react with human.
抗体类型	Monoclonal Antibody
基因符号	HOX2 HOX2F HOX-2.6
纯化方法	Unpurified
UniProt编号	P17483
UniProt汇总	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9 weeks from conception. SEQUENCE SIMILARITIES: Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

产品使用声明
质量保证	Evaluated by Western Blot in K562 cell lysate. Western Blot Analysis: 1:500 dilution of this antibody detected HoxB4 in K562 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing Solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below
-20°C may cause glycerol containing Solutions to become frozen during storage.