- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 AB3349 Replaces MABE551 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-PRMT5 Antibody, CT 产品信息 格式 Purified 控制 - POSITIVE CONTROL: HL60 cell lysates.
演示 Purified immunoglobulin in PBS containing 0.09% sodium azide. 应用 应用 Anti-PRMT5 Antibody, C-terminus is a high quality Rabbit Polyclonal Antibody for the detection of PRMT5 & has been validated in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western Blot: 1:100-1:500. Reacts with a band of approximately 70 kDa on whole HL60 cell lysate. Additional bands may be present depending on sample used.
ELISA (direct): 1:1,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from C-terminus of human PRMT5. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Reacts with PRMT5. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006109.3
- NM_001039619.1
基因符号 - EC 2.1.1.-
- PRMT5
- SKB1
- HRMT1L5
- IBP72
- SKB1Hs
- JBP1
- EC 2.1.1.125
UniProt编号 - O14744
UniProt汇总 FUNCTION: SwissProt: O14744 # Methylates specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 to monomethylarginine and to symmetrical dimethylarginines (sDMAs). Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A/H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription.
SIZE: 637 amino acids; 72684 Da
SUBUNIT: Forms, at least, homodimers and homotetramers. Interacts with PRDM1 (By similarity). Component of the methylosome, a 20S complex containing at least pICLn, PRMT1/SKB1 and MEP50. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Also interacts with Sm proteins, JAK2, SSTR1 and SUPT5H. Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Ubiquitous.
PTM: Disulfide bonds and non-covalent association mediate homooligomers formation.
SIMILARITY: SwissProt: O14744 ## Belongs to the protein arginine N-methyltransferase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,ABN51,Anti-Fox-3 Antibody
下一件merck millipore产品：merck millipore,默克密理博,14-606M,ASK1 Protein, active, 250 µg
相关产品
merck millipore,默克密理博,431784,Lectin, PHA-L, Phaseolus vulgaris
merck millipore,默克密理博,HTS164RTA,Ready-to-Assay™ GLP-2 Glucagon Family Receptor Frozen Cells
merck millipore,默克密理博,CBL130,Anti-CD41 Antibody, clone DD4.1
merck millipore,默克密理博,ABN51,Anti-Fox-3 Antibody
merck millipore,默克密理博,14-606M,ASK1 Protein, active, 250 µg
merck millipore,默克密理博,234505,Compound 56 - CAS 171745-13-4 - Calbiochem
merck millipore,默克密理博,ISEQ10100,Immobilon-PSQ 方片膜，PVDF，0.2 µm，10 x 10 cm
merck millipore,默克密理博,IL012,Interleukin-13 Protein, Recombinant human
merck millipore,默克密理博,MAB2056Z,Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free)