- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC M Purified Monoclonal Antibody 描述 产品目录编号 CBL130 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD41 Antibody, clone DD4.1 Alternate Names - intact Platelet gpIIb/IIIa Complex
产品信息 格式 Purified 演示 The monoclonal is presented at a concentration of 100 μg/1mL in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 Anti-CD41 Antibody, clone DD4.1 is an antibody against CD41 for use in FC, IF, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Immunofluorescence
Flow cytometry
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Medulloblastoma tissue 克隆 DD4.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody recognises the intact platelet gpIIb/IIIa complex, it does not bind to dissociated gpIIb or gpIIIa only to gpIIb in the intact complex. This is found on platelets, megakaryocytes and monocytes. Acute megakaryoblastic leukaemia cells are positive for the gpIIb/IIIa antigen whereas common myeloid leukaemias are negative. Ligand binding occurs in part via an RGD sequence which is known to be of importance for certain other adhesion interactions with extracellular proteins
FUSION PARTNER: NS1 myeloma cell line同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000419.3
Entrez基因汇总 ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. 基因符号 - GTA
- ITGA2B
- CD41B
- HPA3
- CD41
- GPIIb
- GP2B
- ITGAB
UniProt编号 - P08514
UniProt汇总 FUNCTION: SwissProt: P08514 # Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
SIZE: 1039 amino acids; 113391 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
DISEASE: SwissProt: P08514 # Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. This autosomal recessive disorder is the most common inherited disease of platelets. GT is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
SIMILARITY: SwissProt: P08514 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2°-8°C for up to 12 months from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,HTS164RTA,Ready-to-Assay™ GLP-2 Glucagon Family Receptor Frozen Cells
下一件merck millipore产品：merck millipore,默克密理博,ABN51,Anti-Fox-3 Antibody
相关产品
merck millipore,默克密理博,ECM645,Endothelial Cell Adhesion Assay Kit
merck millipore,默克密理博,SF-3043,FOXA2; Human, Cyanine 3 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,431784,Lectin, PHA-L, Phaseolus vulgaris
merck millipore,默克密理博,HTS164RTA,Ready-to-Assay™ GLP-2 Glucagon Family Receptor Frozen Cells
merck millipore,默克密理博,ABN51,Anti-Fox-3 Antibody
merck millipore,默克密理博,AB3349,Anti-PRMT5 Antibody, CT
merck millipore,默克密理博,14-606M,ASK1 Protein, active, 250 µg
merck millipore,默克密理博,234505,Compound 56 - CAS 171745-13-4 - Calbiochem
merck millipore,默克密理博,ISEQ10100,Immobilon-PSQ 方片膜，PVDF，0.2 µm，10 x 10 cm