merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2056Z,Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free)

  • merck millipore,默克密理博,MAB2056Z,Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free)

    产品名称：Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free)
    产品型号：MAB2056Z
    Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free) inhibits cell attachment & detects level of Integrin α3 & has been published & validated for use in FC, IP, IH, Inhibition Assays.

    merck millipore,默克密理博,MAB2056Z,Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free)

  • 产品介绍
  • merck millipore,默克密理博,MAB2056Z,Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, FCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2056Z
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free)
    Alternate Names
    • CD49c
    产品信息
    格式 Purified
    演示 Purified cultured supernatant in 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, without preservatives.
    应用
    应用 Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free) inhibits cell attachment & detects level of Integrin α3 & has been published & validated for use in FC, IP, IH, Inhibition Assays.
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    应用说明 Inhibition (Functional Activity): A previous lot of this antibody was shown to inhibit cell attachment by inhibiting SCC9 cell adhesion to human and EHS laminin, and laminin GD-2 peptide and potentiates the inhibition of SKOV-3 cell adhesion to EHS laminin by anti-integrin alpha 5 antibody GoH3. This antibody does not inhibit cell adhesion to fibronectin or collagen type IV.

    Immunohistochemistry Analysis: A previous lot of this antibody was used on acetone-fixed frozen human epithelial tissues including tongue, foreskin and ovary. Not for use on formalin-fixed tissue.

    Flow Cytometry Analysis: A previous lot of this antibody stains human squamous cell carcinoma (SCC9), ovarian carcinoma (SKOV-3) and umbilical vein endothelial cells (HUVEC).

    Immunoprecipitation Analysis: A previous lot of this antibody precipitates PAGE bands of 130 kDa (reduced) or 116 kDa and 135 kDa (non-reduced) from surface-biotinylated SCC9 or SKOV-3 cells.
    生物信息
    免疫原品种 Human squamous cell carcinoma cells (SCC9)
    克隆 ASC-1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Human alpha3 integrin (CD49c)
    同种型 IgG1κ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005501.1
    • NM_002204.1
    Entrez基因汇总 ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').
    基因符号
    • CD49C
    • ITGA3
    • GAP-B3
    • CD49c
    • FLJ34704
    • MSK18
    • VLA3a
    • VL3A
    • VCA-2
    • FLJ34631
    • FRP-2
    • GAPB3
    UniProt编号
    • P26006
    UniProt汇总 FUNCTION: SwissProt: P26006 # Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
    SIZE: 1066 amino acids; 118698 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells.
    PTM: Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12- myristate 13-acetate stimulation.
    SIMILARITY: SwissProt: P26006 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -20°C in undiluted aliquots.
    Avoid repeated freeze-thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2056Z,Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free)

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