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品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3270 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-K+-Cl- Cotransporter 4 Antibody Alternate Names - KCC4
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in 100 mM Tris, pH 7.5, containing 0.2% BSA and 0.05% sodium azide. 应用 应用 Anti-K+-Cl-Cotransporter 4 Antibody is an antibody against K+-Cl-Cotransporter 4 for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-10 μg/mL using ECL.
Approximate size on reduced westerns is 120-140kDa; membrane preparations and proteinase inhibitors are strongly recommended.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A 16 amino acid peptide within the cytoplasmic, N-terminus of mouse KCC4. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes K+ Cl- Cotransporter-4 (KCC4). The immunogen shows no significant sequence homology with other KCCs or CCC.
SPECIES REACTIVITIES: The immunogen sequence is 81% homologous with human KCC4. Reactivity with other species has not been confirmed.品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006598.2
基因符号 - DKFZP434F076
- SLC12A7
- KCC4
UniProt编号 - Q9Y666
UniProt汇总 FUNCTION: SwissProt: Q9Y666 # Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
SIZE: 1083 amino acids; 119106 Da
SUBUNIT: Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Detected in muscle, brain, lung, heart and kidney.
SIMILARITY: SwissProt: Q9Y666 ## Belongs to the SLC12A transporter family.
MISCELLANEOUS: Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
上一件merck millipore产品：merck millipore,默克密理博,420119,JNK Inhibitor II - CAS 129-56-6 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,655200,TX-1123 - CAS 157397-06-3 - Calbiochem
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