merck millipore,默克密理愽
  • merck millipore,默克密理博,233100,CL-387,785 - CAS 194423-06-8 - Calbiochem

  • merck millipore,默克密理博,233100,CL-387,785 - CAS 194423-06-8 - Calbiochem

    产品名称：CL-387,785 - CAS 194423-06-8 - Calbiochem
    产品型号：233100
    A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC₅₀ = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR  More>>

    merck millipore,默克密理博,233100,CL-387,785 - CAS 194423-06-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,233100,CL-387,785 - CAS 194423-06-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₃BrN₄O194423-06-8
    描述
    概述 A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC50 = 5 nM). Blocks EGF-mediated growth in A431 cells. Inhibits proliferation of EGFR or c-ErbB2 expressing cells (IC50 = 31-125 nM) by covalently binding to the EGFR.
    产品目录编号 233100
    品牌系列 Calbiochem®
    同义词 N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785
    参考
    参考 Sweeney, W.E., et al. 2000. Kidney Int. 57, 33.
    Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917.
    Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.
    产品信息
    CAS号 194423-06-8
    具有ATP竞争性 N
    形式 Pale yellow solid
    Hill配方 C₁₈H₁₃BrN₄O
    化学配方 C₁₈H₁₃BrN₄O
    Molar Mass 381.2
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 EGFR kinase activity
    主靶IC50 250-490 pM inhibiting EGF-receptor (EGFR) kinase activity in vivo; 5 nM inhibiting EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,233100,CL-387,785 - CAS 194423-06-8 - Calbiochem

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