merck millipore,默克密理愽
  • merck millipore,默克密理博,420119,JNK Inhibitor II - CAS 129-56-6 - Calbiochem

  • merck millipore,默克密理博,420119,JNK Inhibitor II - CAS 129-56-6 - Calbiochem

    产品名称：JNK Inhibitor II - CAS 129-56-6 - Calbiochem
    产品型号：420119
    The JNK Inhibitor II, also referenced under CAS 129-56-6, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,420119,JNK Inhibitor II - CAS 129-56-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420119,JNK Inhibitor II - CAS 129-56-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₈N₂O129-56-6
    描述
    概述 A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.
    产品目录编号 420119
    品牌系列 Calbiochem®
    同义词 Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II
    参考
    参考 Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
    Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
    Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
    产品信息
    CAS号 129-56-6
    具有ATP竞争性 Y
    形式 Yellowish orange solid
    Hill配方 C₁₄H₈N₂O
    化学配方 C₁₄H₈N₂O
    Molar Mass 220.2
    可逆 Y
    结构配方图像
    生物信息
    主靶 JNK 1, JNK 2, JNK 3
    主靶IC50 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    GHS安全信息
    RTECS CB4585000
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420119,JNK Inhibitor II - CAS 129-56-6 - Calbiochem

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