merck millipore,默克密理愽
  • merck millipore,默克密理博,655200,TX-1123 - CAS 157397-06-3 - Calbiochem

  • merck millipore,默克密理博,655200,TX-1123 - CAS 157397-06-3 - Calbiochem

    产品名称：TX-1123 - CAS 157397-06-3 - Calbiochem
    产品型号：655200
    A cell-permeable, reversible, and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as an inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC at much higher concentrations.

    merck millipore,默克密理博,655200,TX-1123 - CAS 157397-06-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,655200,TX-1123 - CAS 157397-06-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₄O₃157397-06-3
    描述
    概述 A cell-permeable, reversible, and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as an inhibitor for Src, eEF2-K, and PKA (IC50 = 2.2, 3.2, and 9.6 µM, respectively), while it inhibits EGFR-K and PKC at much higher concentrations (IC50 = 320 µM). Displays potent antitumor activity (EC50 = 3.66 and 39 µM in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥1000-fold) and hepato-toxicity (≥50-fold) when compared with another tyrphostin, AG 17 (Cat. No. 658425). It is therefore a more promising candidate as a therapeutic agent for cancer treatment.
    产品目录编号 655200
    品牌系列 Calbiochem®
    同义词 2-((3,5-di-tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione, PKA Inhibitor XII
    参考
    参考 Hori, H., et al. 2003. Cell. Mol. Biol. Lett. 8, 528.
    Hori, H., et al. 2002. Bioorg. Med. Chem. 10, 3257.
    产品信息
    CAS号 157397-06-3
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₂₀H₂₄O₃
    化学配方 C₂₀H₂₄O₃
    Molar Mass 312.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 Src
    主靶IC50 2.2, 3.2, and 9.6 µM against Src, eEF2-K, and PKA, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (- 20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,655200,TX-1123 - CAS 157397-06-3 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,AB3270,Anti-K+-Cl- Cotransporter 4 Antibody
下一件merck millipore产品：merck millipore,默克密理博,328009,ERK Inhibitor III - CAS 331656-92-9 - Calbiochem


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