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品种反应性 主要应用 宿主 格式 抗体类型 R, B, H, M, Po WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3081 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Na+/H+ Exchanger-1 Antibody Alternate Names - NHE1
产品信息 格式 Affinity Purified 控制 - Kidney tissue (basolateral membrane)
演示 Affinity Purified immunoglobulin. Liquid in 100 mM Tris, pH 7.5 and 0.2% BSA and 0.05% sodium azide. 应用 应用 Detect Na+/H+ Exchanger-1 using this Anti-Na+/H+ Exchanger-1 Antibody validated for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-10 μg/mL using Chemiluminescence technique.
ELISA: 1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 A 22 aa peptide within the cytoplasmic, C-terminal domain of rat NHE1, coupled to KLH. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Na+/H+ Exchanger 1 (NHE1). The immunogen peptide shows no significant homology with other NHE isoforms (NHE2-5). 品种反应性 RatBovineHumanMousePig 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003047.2
基因符号 - NHE1
- SLC9A1
- APNH
- +H
- APNH1
- FLJ42224
- NHE-1
- Na
纯化方法 Immunoaffinity purified UniProt编号 - P19634
UniProt汇总 FUNCTION: SwissProt: P19634 # Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
SIZE: 815 amino acids; 90763 Da
SUBUNIT: Interacts with tescalcin, CHP and CHP2.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Kidney and intestine.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. & O-glycosylated.
SIMILARITY: SwissProt: P19634 ## Belongs to the Na(+)/H(+) exchanger (TC 2.A.36.5.1) family.
MISCELLANEOUS: Inhibited by amiloride and 5-amino-substituted derivatives and activated in a cooperative fashion by intracellular H(+). In quiescent cells upon growth factor stimulation, the apparent affinity for internal H(+) is increased, resulting in a persistent rise in cytoplasmic pH.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 50 µg
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