merck millipore,默克密理博,AB2284,Anti-RBP-jk Antibody

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merck millipore,默克密理博,AB2284,Anti-RBP-jk Antibody
产品名称：Anti-RBP-jk Antibody
产品型号：AB2284
Anti-RBP-jk Antibody detects level of RBP-jk & has been published & validated for use in WB.

merck millipore,默克密理博,AB2284,Anti-RBP-jk Antibody

产品介绍

merck millipore,默克密理博,AB2284,Anti-RBP-jk Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Zebrafish, R, M, H, Ch, Dr, Eq, Nem	WB	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	AB2284
描述	Anti-RBP-jk Antibody
Alternate Names	suppressor of hairless homolog H-2K binding factor-2 J kappa-recombination signal-binding protein RBP-J kappa Renal carcinoma antigen NY-REN-30 immunoglobulin kappa J region recombination signal binding protein 1 recombination signal binding protein for immunoglobulin kappa J region recombining binding protein suppressor of hairless recombining binding protein suppressor of hairless<br />(Drosophila)
背景信息	RBP-jk, Recombinant signal binding protein for immunoglobin kappa J region, is a human homolog for the Drosophila gene, suppressor of hairless. RBP-jk is located in the nucleus and is a 60 kDa monomeric protein that is used as a promoter region in notch signaling. Notch signaling is important in cell to cell communication which allows "a differentiating cell to suppress the same differentiation fate in a neighboring cell (the receiving cell). This ensures that the correct number of cells are distributed to distinct cell fates." When RBP-jk is not associated with Notch proteins, it acts as a transcriptional repressor. A disease associated with RBP-jk is the Epstein Barr virus.

产品信息
格式	Purified
控制	HepG2 and mouse liver cell lysates.
演示	Purified rabbit polyclonal in PBS containing 0.05% NaN3.

应用
应用	Anti-RBP-jk Antibody detects level of RBP-jk & has been published & validated for use in WB.
主要应用	Western Blotting
应用说明	Western Blotting: HepG2 Lysate.

生物信息
免疫原品种	Synthetic Linear peptide corresponding to the Beta-Trefoil Domain a.a. 194-206 of RBP-jk conjugated to KLH.
表位	Beta-Trefoil Domain
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	Cat. # AB2284 recognizes the Beta-Trefoil Domain of RBP-jk.
品种反应性	ZebrafishRatMouseHumanChickenDrosophilaHorseNematode
Species Reactivity Note	Proven to react with Human and Mouse. Predicted to react with Drosophila, Hydra, Horse, rat, Danio, and chicken based on sequence homology. Reactivity with other species has not been determined.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_005349.2
基因符号	csl CBF-1 CBF1 IGKJRB IGKJRB1 KBF2 MGC61669 OTTHUMP00000123440 OTTHUMP00000123441 RBP-J RBP-JK RBPJK RBPSUH SUH
纯化方法	Ammonium sulfate precipitation
UniProt编号	Q06330
UniProt汇总	FUNCTION:Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate. determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. SUBUNIT STRUCTURE: Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR. Interacts with EP300, MAML1 and PTF1A. Ref.4 Ref.5 Ref.6 SUBCELLULAR LOCATION: Nucleus. Ref.4 SIMILARITY: Belongs to the Su(H) family. Contains 1 IPT/TIG domain. CAUTION:Despite some similarity with the "phage" integrase family, it has no recombinase activity.

产品使用声明
质量保证	Western Blotting: 1:1,000 dilution from a previous lot detected RBP-jk on 10 µg of mouse liver or HepG2 lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8ºC from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,AB2284,Anti-RBP-jk Antibody

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