merck millipore,默克密理博,14-435,DYRK1A Protein, active, 10 µg

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merck millipore,默克密理博,14-435,DYRK1A Protein, active, 10 µg
产品名称：DYRK1A Protein, active, 10 µg
产品型号：14-435
Active, recombinant rat DYRK1A, corresponding to N-terminal amino acid residues 1-499, containing an N-terminal GST-tag, for use in Kinase Assays.

merck millipore,默克密理博,14-435,DYRK1A Protein, active, 10 µg

产品介绍

merck millipore,默克密理博,14-435,DYRK1A Protein, active, 10 µg

描述
产品目录编号	14-435
品牌系列	Upstate
商名	Upstate
描述	DYRK1A Protein, active, 10 µg
概述	Recombinant rat DYRK1A, corresponding to N-terminal amino acid residues 1-499, containing an N-terminal GST-tag

应用
应用	Active, recombinant rat DYRK1A, corresponding to N-terminal amino acid residues 1-499, containing an N-terminal GST-tag, for use in Kinase Assays.
主要应用	Kinase Assay

生物信息
来源	expressed in E. coli
品种	Rat
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez基因编号	NM_130438.2 NM_001396.3 NM_101395.2 NM_130436.2 NM_130437.2
Entrez基因汇总	This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
基因符号	MNB DYRK1A HP86 DYRK DYRK1 MNBH hMNB
蛋白靶	DYRK1A
纯化方法	GSH-agarose chromatography
靶子系列	CMGC
UniProt编号	Q13627
UniProt汇总	FUNCTION: SwissProt: Q13627 # May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates. SIZE: 763 amino acids; 85584 Da SUBUNIT: Interacts with RANBP9. SUBCELLULAR LOCATION: Nucleus speckle. TISSUE SPECIFICITY: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. DEVELOPMENTAL STAGE: Expressed in the developing central nervous system. PTM: Autophosphorylated on tyrosine residues. DISEASE:SwissProt: Q13627 # Overexpressed 1.5-fold in fetal Down syndrome brain. SIMILARITY: SwissProt: Q13627 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. & Contains 1 protein kinase domain.

产品使用声明
质量保证	routinely evaluated by phosphorylation of 50mM Woodtide substrate peptide
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	6 months at -20C

包装信息
数量	10 µg
包装	Also available in 250 µg size --call for pricing and availability and reference catalog number 14-435M when ordering the 250 µg size.

merck millipore,默克密理博,14-435,DYRK1A Protein, active, 10 µg

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