merck millipore,默克密理愽
  • merck millipore,默克密理博,AB2226,Anti-MDGA1 Antibody

  • merck millipore,默克密理博,AB2226,Anti-MDGA1 Antibody

    产品名称：Anti-MDGA1 Antibody
    产品型号：AB2226
    Anti-MDGA1 Antibody detects level of MDGA1 & has been published & validated for use in Western Blotting.

    merck millipore,默克密理博,AB2226,Anti-MDGA1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB2226,Anti-MDGA1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, M, R, BWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB2226
    描述 Anti-MDGA1 Antibody
    Alternate Names
    • MAM domain-containing protein 3
    • MAM domain-containing glycosylphosphatidylinositol anchor protein 1
    • GPI and MAM protein
    • GPIM
    • Glycosylphosphatidylinositol-MAM
    背景信息 Studies report that MDGA1 is a layer-specific marker and an area-specific marker, being expressed in layers 2/3 throughout the neocortex, but within the primary somatosensory area (S1), MDGA1 is also uniquely expressed in layers 4 and 6a. Comparisons with other markers, including cadherins, serotonin, cytochrome oxidase, RORß, and COUP-TF1, reveal unique features of patterned expression of MDGA1 within cortex and S1 barrels. Furthermore, during early stages of development, MDGA1 is expressed by Reelin- and Tbr1-positive Cajal–Retzius neurons that originate from multiple sources outside of neocortex and emigrate into it. At even earlier stages, MDGA1 is expressed by the earliest diencephalic and mesencephalic neurons, which appear to migrate from a MDGA1-positive domain of progenitors in the diencephalon and form a "preplate." These findings show that MDGA1 is a unique marker for studies of cortical lamination and area patterning and together with recent reports suggest that MDGA1 has critical functions in forebrain/midbrain development.
    产品信息
    格式 Affinity Purified
    控制
    • Untreated and PNGase F treated mouse P7 brain tissue lysate.
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-MDGA1 Antibody detects level of MDGA1 & has been published & validated for use in Western Blotting.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the MAM domain of MDGA1.
    表位 MAM domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the MAM domain of MDGA1.
    品种反应性 HumanMouseRatBovine
    Species Reactivity Note Demonstrated to react with Mouse and Rat. Predicted to react with Bovine and Human based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_705691
    基因符号
    • MAMDC3
    • MDGA1
    纯化方法 Affinity purified
    UniProt编号
    • Q8NFP4
    UniProt汇总 FUNCTION: Required for radial migration of cortical neurons in the superficial layer of the neocortex.

    SUBUNIT STRUCTURE: Interacts heterophilically through its MAM domain with proteins in axon-rich regions and through its Ig-like domains with proteins in differentiating muscle.

    SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor. Note: Associated with lipid rafts.

    TISSUE SPECIFICITY: Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.
    产品使用声明
    质量保证 Evaluated by Western Blot in untreated and PNGase F treated mouse P7 brain tissue lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected MDGA1 in 5 µg of untreated and PNGase F treated mouse P7 brain tissue lysate. This antibody recognizes glycosolated (>160 kDa) (lane 1) and deglycosolated MDGA1 (lane 2).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB2226,Anti-MDGA1 Antibody

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