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merck millipore,默克密理博,04-146,Anti-NLRX1 Antibody
产品名称：Anti-NLRX1 Antibody
产品型号：04-146
Use Anti-NLRX1 Antibody (Mouse Monoclonal Antibody) validated in WB to detect NLRX1 also known as NLR family member X1, Nucleotide-binding oligomerization domain protein 9, Caterpiller protein 11.3.
merck millipore,默克密理博,04-146,Anti-NLRX1 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 04-146 描述 Anti-NLRX1 Antibody Alternate Names - nucleotide-binding oligomerization domain, leucine rich repeat containing X1
- NLR family member X1
- NLR family, X1
- Nucleotide-binding oligomerization domain protein 9
- Caterpiller protein 11.3
- Nucleotide-binding oligomerization domain protein 5
- NOD-like receptor X1
- Nucleotide-binding oligomerization domain protein 26
背景信息 NLR family member X1 (NLRX1) belongs to the Nod-like receptor (NLR) family of proteins, a group of proteins characterized by their highly conserved nucleotide binding domain (NBD) and their leucine-rich-repeats (LRR). NLRX1 is the only member of this family localized to mitochondria, where it plays a role in antiviral signaling by blocking virus-induced interaction of RLH-MAVS, serving as a negative regulator of the antiviral responses mediated by MAVS. It also serves to up-regulate NF-Kappa-B and JNK-dependent signaling cascades as its overexpression induces reactive oxygen species (ROS). NLRX1 has been observed in high quantities within the heart, mammary gland, and muscle tissues. It has also been observed at the protein level in various cell lines including; JURKAT, HeLa, HL60, RAJI, THP-1, and 293T. 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-NLRX1 Antibody (Mouse Monoclonal Antibody) validated in WB to detect NLRX1 also known as NLR family member X1, Nucleotide-binding oligomerization domain protein 9, Caterpiller protein 11.3. 主要应用 - Western Blotting
应用说明 Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF to detect NLRX1 in the mitochondria of the cytosol (Moore, C. B., Ting, J.P-Y., et al., 2008).
Immunogold-bead Electron Micrography: A previous lot was used by an independent laboratory to detect NLRX1 in the outer mitochondrial membrane by electron micrography (Moore, C. B., Ting, J.P-Y., et al., 2008).生物信息 免疫原品种 Histidine-tagged recombinant protein corresponding to human NLRX1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_078894
Entrez基因汇总 This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq]. 基因符号 - NOD5
- NOD26
- NOD9
- NLRX1
- DLNB26
纯化方法 Protein G Purified UniProt编号 - Q86UT6
UniProt汇总 FUNCTION: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (Ref.9). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (Ref.8).
SUBUNIT STRUCTURE: Interacts with MAVS.
SUBCELLULAR LOCATION: Mitochondrion outer membrane
TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).
SEQUENCE SIMILARITIES: Belongs to the NLRP family.
Contains 4 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
SEQUENCE CAUTION: The sequence BAB15075.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAG51714.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG51714.1 differs from that shown. Reason: Erroneous termination at position 951. Translated as Trp.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected NLRX1 in 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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