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  • merck millipore,默克密理博,ABD12,Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody

  • merck millipore,默克密理博,ABD12,Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody

    产品名称：Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody
    产品型号：ABD12
    This Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody is validated for use in WB for the detection of Aldehyde dehydrogenase 1 (ALDH1A1).

    merck millipore,默克密理博,ABD12,Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABD12,Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABD12
    描述 Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody
    Alternate Names
    • aldehyde dehydrogenase, liver cytosolic
    • aldehyde dehydrogenase 1 family, member A1
    • ALDH class 1
    • Aldehyde dehydrogenase, cytosolic
    • retinaldehyde dehydrogenase 1
    • Aldehyde dehydrogenase family 1 member A1
    • retinal dehydrogenase 1
    • acetaldehyde dehydrogenase 1
    • aldehyde dehydrogenase 1, soluble
    背景信息 Aldehyde dehydrogenase 1A1 (ALDH1A1) is also known as retinal dehydrogenase 1. It is thought to be a main converter of retinol to retinoic acid, which is very important in cell to cell signaling. ALDH1A1 may also be involved in inhibiting invasion in pancreatic cancer cells. More specifically, ALDH1A1 may regulate hematopoietic stem cell differentiation by disrupting the retinoid signaling.
    产品信息
    格式 Affinity Purified
    控制
    • HepG2 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody is validated for use in WB for the detection of Aldehyde dehydrogenase 1 (ALDH1A1).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Aldehyde dehydrogenase 1.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    Other homologies: rat and mouse (91% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_000680
    Entrez基因汇总 This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq].
    基因符号
    • ALDH1A1
    • RALDH1
    • ALDH11
    • ALHDII
    • ALDC
    • ALDH-E1
    • ALDH1
    • PUMB1
    • RalDH1
    • RALDH 1
    纯化方法 Affinity purified
    UniProt编号
    • P00352
    UniProt汇总 FUNCTION: Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).

    CATALYTIC ACTIVITY: Retinal + NAD+ + H2O = retinoate + NADH.

    PATHWAY: Cofactor metabolism; retinol metabolism.

    SUBUNIT STRUCTURE: Homotetramer.

    SUBCELLULAR LOCATION: Cytoplasm.

    SEQUENCE SIMILARITIES: Belongs to the aldehyde dehydrogenase family.
    产品使用声明
    质量保证 Evaluated by Western Blot in HepG2 cell lysate.

    Western Blot Analysis: 0.05 µg/mL of this antibody detected Aldehyde dehydrogenase 1 on 10 µg of HepG2 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABD12,Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody

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