merck millipore,默克密理愽
  • merck millipore,默克密理博,12-323,Caspase 3 Fluorometric Substrate

  • merck millipore,默克密理博,12-323,Caspase 3 Fluorometric Substrate

    产品名称：Caspase 3 Fluorometric Substrate
    产品型号：12-323
    Caspase 3 Fluorometric Substrate (Ac-Asp-Glu-Val-Asp-AMC) for use in Capase activity assays. Can be used to assay Apopain activity in vitro.

    merck millipore,默克密理博,12-323,Caspase 3 Fluorometric Substrate

  • 产品介绍
  • merck millipore,默克密理博,12-323,Caspase 3 Fluorometric Substrate

    重要规格表

    主要应用 检测方法
    ACTFluorescent
    描述
    产品目录编号 12-323
    品牌系列 Upstate
    商名
    • Upstate
    描述 Caspase 3 Fluorometric Substrate
    产品信息
    检测方法 Fluorescent
    演示 Lyophilized powder.
    应用
    应用 Caspase 3 Fluorometric Substrate (Ac-Asp-Glu-Val-Asp-AMC) for use in Capase activity assays. Can be used to assay Apopain activity in vitro.
    主要应用
    • Activity Assay
    生物信息
    Entrez基因编号
    • NM_032991.2
    • NM_004346.3
    Entrez基因汇总 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
    基因符号
    • Yama
    • CASP3
    • apopain
    • CASP-3
    • procaspase3
    • CPP32B
    • SCA-1
    • CPP-32
    • Apopain
    • CPP32
    UniProt编号
    • P42574
    UniProt汇总 FUNCTION: SwissProt: P42574 # Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
    SIZE: 277 amino acids; 31608 Da
    SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
    PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
    SIMILARITY: SwissProt: P42574 ## Belongs to the peptidase C14 family.
    产品使用声明
    质量保证 Routinely evaluated in an Apopain activity assay as described in (Nicholson, D.W., et al., Nature 376: 37-43, 1995).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Lypholized: 2 years at -20°C. Rehydrated: 4 months at -20°C.
    包装信息
    数量 5 mg

    merck millipore,默克密理博,12-323,Caspase 3 Fluorometric Substrate

上一件merck millipore产品：merck millipore,默克密理博,16-206,Anti-phospho-MBP Antibody, HRP conjugate
下一件merck millipore产品：merck millipore,默克密理博,PP6421-K,IgG Rabbit Purified (1gm)


相关产品

merck millipore,默克密理博,SF-1095,miR-124-3p; Mouse, Cyanine 3, RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1095,miR-124-3p; Mouse, Cyanine 3, RNA Detection Probe,SmartFlare

merck millipore,默克密理博,04-1088,Anti-Caspase-3 (Pro) Antibody, clone E83-103, rabbit monoclonal merck millipore,默克密理博,04-1088,Anti-Caspase-3 (Pro) Antibody, clone E83-103, rabbit monoclonal

merck millipore,默克密理博,MAB1130,Anti-c-abl Antibody, clone 8E9 merck millipore,默克密理博,MAB1130,Anti-c-abl Antibody, clone 8E9

merck millipore,默克密理博,MABC32,Anti-p62 (Sequestosome-1) Antibody, clone 11C9.2 merck millipore,默克密理博,MABC32,Anti-p62 (Sequestosome-1) Antibody, clone 11C9.2

merck millipore,默克密理博,16-206,Anti-phospho-MBP Antibody, HRP conjugate merck millipore,默克密理博,16-206,Anti-phospho-MBP Antibody, HRP conjugate

merck millipore,默克密理博,PP6421-K,IgG Rabbit Purified (1gm) merck millipore,默克密理博,PP6421-K,IgG Rabbit Purified (1gm)

merck millipore,默克密理博,MSHVN4B10,Multiscreen HTS 96 HV Filter Plate, Opaque merck millipore,默克密理博,MSHVN4B10,Multiscreen HTS 96 HV Filter Plate, Opaque

merck millipore,默克密理博,HTS099LT,ChemiBrite™ EP1 Prostanoid Family Receptor Frozen Cells merck millipore,默克密理博,HTS099LT,ChemiBrite™ EP1 Prostanoid Family Receptor Frozen Cells

merck millipore,默克密理博,670111,UDP-α-D-Galactose, Disodium Salt - CAS 137868-52-1 - Calbiochem merck millipore,默克密理博,670111,UDP-α-D-Galactose, Disodium Salt - CAS 137868-52-1 - Calbiochem

merck millipore,默克密理博,ABD12,Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody merck millipore,默克密理博,ABD12,Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部