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  • merck millipore,默克密理博,AB19021,Anti-α-Catenin Antibody

  • merck millipore,默克密理博,AB19021,Anti-α-Catenin Antibody

    产品名称：Anti-α-Catenin Antibody
    产品型号：AB19021
    Detect α-Catenin using this Anti-α-Catenin Antibody validated for use in ELISA, IP, WB, IC, IH(P).

    merck millipore,默克密理博,AB19021,Anti-α-Catenin Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB19021,Anti-α-Catenin Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, Ca, HICC, ELISA, WBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB19021
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-α-Catenin Antibody
    背景信息 The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function (Gumbiner et al. 1993). a-catenin is a 102 kDa protein that is associated with the cadherin indirectly through its interaction with beta-catenin and gamma-catenin (Fouquet et al. 1992). beta-Catenin and its homolog plakoglobin associate directly with the cadherin (Butz et al. 1994). Thus, the cell-cell adherens junction is a structure composed of the transmembrane cadherin, which is associated directly with either beta-catenin or plakoglobin, which in turn assoctiates directly with alpha-catenin. alpha-catenin then mediates the interaction between the cadherin-catenin complex and the actin cytoskeleton (Nagafuchi et al. 1994; Shahidul et al. 1996). alpha-catenin has been characterized as a tumor suppressor, suggesting that it may have a regulatory function in regulation to its structural role (Rudiger 1998).
    产品信息
    格式 Serum
    演示 Serum. Liquid containing no preservatives.
    应用
    应用 Detect α-Catenin using this Anti-α-Catenin Antibody validated for use in ELISA, IP, WB, IC, IH(P).
    主要应用
    • Immunocytochemistry
    • ELISA
    • Western Blotting
    应用说明 Western blot

    Immunocytochemistry

    Immunohistochemistry on formalin-fixed paraffin-embedded tissues*: 1:250-1:500 *requires pressure cooker antigen retrieval method (Nagafuchi et al. 1994).

    Immunoprecipitation

    ELISA

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Recombinant GST-fusion protein (amino terminal; 576 amino acids)
    宿主 Rabbit
    品种反应性 MouseCanineHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001903.2
    基因符号
    • alphaE-catenin
    • CTNNA1
    • FLJ36832
    • alpha-E-catenin
    • CAP102
    • alpha-catenin
    UniProt编号
    • P35221
    UniProt汇总 FUNCTION: SwissProt: P35221 # Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.
    SIZE: 906 amino acids; 100071 Da
    SUBUNIT: Binds MLLT4 and F-actin (By similarity). Interacts directly with PSEN1 and CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21.
    SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, adherens junction; Cytoplasmic side. Cell junction; Cytoplasmic side. Note=Found at cell-cell boundaries and probably at cell- matrix boundaries.
    TISSUE SPECIFICITY: Expressed ubiquitously in normal tissues.
    PTM: Sumoylated.
    DISEASE:SwissProt: P35221 # Abnormalities of alpha-catenin are involved in the process of cancer invasion and metastasis.
    SIMILARITY: SwissProt: P35221 ## Belongs to the vinculin/alpha-catenin family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB19021,Anti-α-Catenin Antibody

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