merck millipore,默克密理愽
  • merck millipore,默克密理博,565852,PTP Inhibitor XXXI, II-B08 - Calbiochem

  • merck millipore,默克密理博,565852,PTP Inhibitor XXXI, II-B08 - Calbiochem

    产品名称：PTP Inhibitor XXXI, II-B08 - Calbiochem
    产品型号：565852
    The PTP Inhibitor XXXI, II-B08 controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,565852,PTP Inhibitor XXXI, II-B08 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,565852,PTP Inhibitor XXXI, II-B08 - Calbiochem

    重要规格表

    经验配方
    C₃₃H₂₇N₅O₄
    描述
    概述 A cell-permeable indolo-salicylic acid compound that is shown to target SHP2 catalytic domain and inhibit SHP2-catalyzed pNPP hydrolysis (IC50 = 5.5 µM) in a reversible and non-competitive manner (Ki = 5.2 µM), exhibiting 2.6- to 5.7-fold selectivity over PTP1B, SHP1, FAP1, Lyp, CD45, and LMWPTP (IC50 = 14.3, 15.7, 20.3, 25.0, 30.0, and 31.1 µM, respectively). Effectively blocks SHP2-mediated human hematopoietic progenitor cell hyperproliferation (10 µM) due to SHP2 mutations (D61Y and E76K) or GM-CSF stimulation, as well as c-kit-dependent (due to D814V mutation or via ligand stimulation), SHP2-mediated myeloid proliferation (5 to 75 µM). Dual PI-3K and SHP2 inhibition by LY294002 (Cat. Nos. 440202 & 440204) and II-B08 (10 mg/kg and 50 mg/kg, respectively; daily i.p.) is shown to greatly prolong the survival rate of mice bearing D814V KIT-expressing 32D cells in vivo.
    产品目录编号 565852
    品牌系列 Calbiochem®
    同义词 CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX, SHP2 Inhibitor VI, 3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
    参考
    参考 Mali, R.S., et al. 2012. Blood 120, 2669.
    Zhang, X., et al. 2010. J. Med. Chem. 53, 2482.
    产品信息
    形式 Yellowish white powder
    Hill配方 C₃₃H₂₇N₅O₄
    化学配方 C₃₃H₂₇N₅O₄
    Molar Mass 557.6
    可逆 Y
    结构配方图像
    生物信息
    主靶 SHP2
    主靶IC50 5.5, 9.0 and 10.8 µ
    主靶Ki 5.2 µ
    副靶 Other PTPs
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,565852,PTP Inhibitor XXXI, II-B08 - Calbiochem

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