merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL263,Anti-MUC-1 Antibody, 12-mer epitope, clone VU 3C6

  • merck millipore,默克密理博,CBL263,Anti-MUC-1 Antibody, 12-mer epitope, clone VU 3C6

    产品名称：Anti-MUC-1 Antibody, 12-mer epitope, clone VU 3C6
    产品型号：CBL263
    Anti-MUC-1 Antibody, 12-mer epitope, clone VU 3C6 detects level of MUC-1 & has been published & validated for use in WB, IH, IH(P).

    merck millipore,默克密理博,CBL263,Anti-MUC-1 Antibody, 12-mer epitope, clone VU 3C6

  • 产品介绍
  • merck millipore,默克密理博,CBL263,Anti-MUC-1 Antibody, 12-mer epitope, clone VU 3C6

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL263
    Replaces CBL264
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-MUC-1 Antibody, 12-mer epitope, clone VU 3C6
    Alternate Names
    • CD227
    • Breast carcinoma-associated antigen DF3
    • Carcinoma-associated mucin
    • Episialin
    • H23AG
    • PEMT
    • Peanut-reactive urinary mucin
    • PUM
    • Polymorphic epithelial mucin
    • PEM
    • Tumor-associated epithelial membrane antigen
    • EMA
    • Tumor-associated mucin
    产品信息
    格式 Purified
    演示 The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
    应用
    应用 Anti-MUC-1 Antibody, 12-mer epitope, clone VU 3C6 detects level of MUC-1 & has been published & validated for use in WB, IH, IH(P).
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Western blotting.

    Suitable for use on formalin fixed paraffin wax embedded tissue sections. HIER (Microwave, citrate buffer pH6.0) may be advantageous for some applications.

    Suitable for use on frozen tissue sections.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Human breast cancer cell line ZR-75-1.
    表位 12-mer epitope
    克隆 VU 3C6
    宿主 Mouse
    特异性 The antibody reacts with the extracellular 12-mer GVTSAPDTRPAP epitope of the MUC-1 tandem repeat.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002456.4
    • NM_001018021.1
    • NM_001018016.1
    • NM_001018017.1
    • NM_001044390.1
    • NM_001044391.1
    • NM_001044392.1
    • NM_001044393.1
    Entrez基因汇总 This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.
    基因符号
    • CD227
    • MUC1
    • MUC-1/X
    • PEMT
    • MUC-1/SEC
    • PUM
    • MUC1/ZD
    • MUC-1
    • Episialin
    • episialin
    • EMA
    • PEM
    • H23AG
    • MAM6
    UniProt编号
    • P15941
    UniProt汇总 FUNCTION: SwissProt: P15941 # Isoform 7 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.
    SIZE: 1255 amino acids; 122072 Da
    SUBUNIT: The cleaved form (only the isoform 1) of MUC1 forms a tight heterodimer with the released C-terminal peptide (which is first secreted to be extracellular).
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 5: Secreted. & Isoform 9: Secreted.
    TISSUE SPECIFICITY: Expressed on ductal epithelial cells and on activated T-cells. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 expressed only in tumoral cells.
    PTM: Highly glycosylated (N- and O-linked carbohydrates and sialic acid). In the 20 amino acid tandem repeat positions 5 (Ser), 6 (Thr), 14 (Thr), 15 (Ser) and 19 (Thr) are O-glycosylated (GalNAc). The average density of O-glycosylated sites within repeat peptides varies with cell differentiation from about 50% in lactation-associated MUC1 to over 90% in a variety of breast cancer cells. & Isoform 1 and isoform 7 undergoes transphosphorylation on serine and tyrosine residues.
    SIMILARITY: SwissProt: P15941 ## Contains 1 SEA domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,CBL263,Anti-MUC-1 Antibody, 12-mer epitope, clone VU 3C6

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