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品种反应性 主要应用 宿主 格式 抗体类型 Ca, R, H, B, Eq, Rhesus Macaque, Chp, M WB, IHC Gp Serum Polyclonal Antibody 描述 产品目录编号 AB2255 Replaces AB5394 描述 Anti-GABA B Receptor R2 Antibody Alternate Names - GABA(B)R2
- G protein-coupled receptor 51
- G-protein coupled receptor 51
- GABA-B receptor 2
- gamma-aminobutyric acid (GABA) B receptor, 2
- gamma-aminobutyric acid B receptor, 2
- GABA-B-R2
背景信息 Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants. 产品信息 格式 Serum 控制 - Purkinje cells in rat mid-brain region
演示 Unpurified guinea pig polyclonal serum with 0.05% sodium azide. 应用 应用 Anti-GABA B Receptor R2 Antibody is an antibody against GABA B Receptor R2 for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
生物信息 免疫原品种 Bovine thyroglobulin-conjugated linear peptide at the C-terminus of rat GABA-B-R2. 表位 C-terminus 宿主 Guinea Pig 特异性 This antibody recognizes the C-terminus of rat GABA-B-R2. 品种反应性 CanineRatHumanBovineHorseRhesus MacaqueChimpanzeeMouse Species Reactivity Note Demonstrated to react with rat. Predicted to react with human, bovine, horse, rhesus monkey, chimpanzee, mouse, and canine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_113990
Entrez基因汇总 GABA-B-R2 combines with GABA-B1 to form functional GABA-B receptors; inhibits high voltage activated calcium ion channels [RGD]. 基因符号 - HG20
- GABBR2
- GABA-B-R2
- GABABR2
- GPR51
- GPRC3B
- Gb2
纯化方法 Unpurified UniProt编号 - O88871
UniProt汇总 FUNCTION: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
SUBUNIT STRUCTURE: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Note: Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
TISSUE SPECIFICITY: Expressed in brain cortex, hippocampus, medial habenula, thalamus and cerebellum. Coexpression is seen in cerebellum.
DEVELOPMENTAL STAGE: Abundant in brain cortex and cerebellum throughout postnatal development whereas its expression in spinal cord gradually decreases.
DOMAIN: Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.产品使用声明 质量保证 Evaluated by Immunohistochemistry in Purkinje cells in rat mid-brain region.
Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected GABA-B-R2 in Purkinje cells in rat mid-brain region.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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