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  • merck millipore,默克密理博,AB19001,Anti-ADAM 21 Antibody, CT

  • merck millipore,默克密理博,AB19001,Anti-ADAM 21 Antibody, CT

    产品名称：Anti-ADAM 21 Antibody, CT
    产品型号：AB19001
    Anti-ADAM 21 Antibody, C-terminus detects level of ADAM 21 & has been published & validated for use in ELISA, WB, IC, IH.

    merck millipore,默克密理博,AB19001,Anti-ADAM 21 Antibody, CT

  • 产品介绍
  • merck millipore,默克密理博,AB19001,Anti-ADAM 21 Antibody, CT

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIHC, ELISA, WB, ICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB19001
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-ADAM 21 Antibody, CT
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS containing 1% BSA.
    应用
    应用 Anti-ADAM 21 Antibody, C-terminus detects level of ADAM 21 & has been published & validated for use in ELISA, WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Western Blotting
    • Immunocytochemistry
    不建议的应用
    • Flow Cytometry
    应用说明 Western blot: (1:1000); 5% purified casein in PBS for blocking. Major unprocessed forms are 100kDa with process forms starting at 90kDa, smaller fragments can be seen as well.

    Immunocytochemistry: (1:100)

    Immunohistochemistry: (1:100)

    ELISA:

    IP: not tested

    FACS: Not Suitable

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 13 amino acid synthetic peptide to the carboxy terminal region
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 ADAM 21
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003813.2
    Entrez基因汇总 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene lacks introns and its expression is testis-specific.
    基因符号
    • EC 3.4.24.-
    • ADAM21
    • ADAM31
    • MGC125389
    UniProt编号
    • Q9UKJ8
    UniProt汇总 FUNCTION: SwissProt: Q9UKJ8 # May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.
    COFACTOR: Binds 1 zinc ion per subunit (Potential).
    SIZE: 722 amino acids; 80820 Da
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: Q9UKJ8 A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding. & The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion. & The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    PTM: Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.
    SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain.
    MISCELLANEOUS: May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB19001,Anti-ADAM 21 Antibody, CT

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