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品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, FC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-785 Replaces 04-460 品牌系列 Upstate
商名 - Upstate
描述 Anti-CD3ε Antibody, clone APA1/1 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide 应用 应用 Detect CD3ε using this Anti-CD3ε Antibody, clone APA1/1 validated for use in FC, IP, WB & IC. 主要应用 - Immunocytochemistry
- Flow Cytometry
- Western Blotting
应用说明 Clone APA1/1 has been demonstrated to recognize a site on CD3&epsilon: that is exposed upon engagement of the T-Cell Receptor complex. Exposure of this neoepitope precedes CD3 phosphorylation and recruitment and activation of ZAP-70, which initiates the signaling cascade produced by T-cell activation. As such, clone APA1/1 provides the earliest known marker for T-Cell Receptor engagement, and thus T-cell activation. 生物信息 免疫原品种 Purified human CD3 epsilon 克隆 APA1/1 宿主 Mouse 特异性 CDε 同种型 IgG1 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000733
Entrez基因汇总 The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. 基因符号 - TCRE
- CD3E
- T3E
纯化方法 Protein G purfied UniProt编号 - P07766
UniProt汇总 FUNCTION: SwissProt: P07766 # The CD3 complex mediates signal transduction.
SIZE: 207 amino acids; 23147 Da
SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P07766 ## Contains 1 Ig-like (immunoglobulin-like) domain. & Contains 1 ITAM domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from Jurkat cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at 2-8°C from date of shipment. 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,08-142,SUMO1 Protein
下一件merck millipore产品：merck millipore,默克密理博,539660,PKCε, Human, Recombinant, S. frugiperda
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