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merck millipore,默克密理博,05-512,Anti-TCF-3/4 Antibody, clone 6F12-3
产品名称：Anti-TCF-3/4 Antibody, clone 6F12-3
产品型号：05-512
Anti-TCF-3/4 Antibody, clone 6F12-3 is a high quality Mouse Monoclonal Antibody for the detection of TCF-3/4 & has been validated in EMSA, IP, WB & IHC.
merck millipore,默克密理博,05-512,Anti-TCF-3/4 Antibody, clone 6F12-3
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H IHC, EMSA, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-512 品牌系列 Upstate
商名 - Upstate
描述 Anti-TCF-3/4 Antibody, clone 6F12-3 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-TCF-3/4 Antibody, clone 6F12-3 is a high quality Mouse Monoclonal Antibody for the detection of TCF-3/4 & has been validated in EMSA, IP, WB & IHC. 主要应用 - Immunohistochemistry
- Electrophoretic Mobility Shift Assay
- Western Blotting
生物信息 免疫原品种 His-tagged fusion protein corresponding to residues 31-331 of human TCF-4 克隆 6F12-3 宿主 Mouse 特异性 TCF-3 and TCF-4 同种型 IgG1 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_031283
基因符号 - E2A
- TCF3
- MGC129648
- MGC129647
- TCF-3
- ITF1
纯化方法 Protein G chromatography UniProt编号 - P15923
UniProt汇总 FUNCTION: SwissProt: P15923 # Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
SIZE: 654 amino acids; 67600 Da
SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with GRIPE and FIGLA (By similarity). Interacts with PTF1A and TGFB1I1. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity). Interacts with UBE2I.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated following NGF stimulation (By similarity).
DISEASE: SwissProt: P15923 # Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1; Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.
SIMILARITY: SwissProt: P15923 ## Contains 1 basic helix-loop-helix (bHLH) domain.产品使用声明 质量保证 routinely evaluated by immunoblot on whole cell lysates of transfected Cos-1 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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