- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,AB1252,Anti-Cytochrome P450 Enzyme CYP2E1 Antibody
产品名称：Anti-Cytochrome P450 Enzyme CYP2E1 Antibody
产品型号：AB1252
Anti-Cytochrome P450 Enzyme CYP2E1 Antibody is an antibody against Cytochrome P450 Enzyme CYP2E1 for use in IH & WB.
merck millipore,默克密理博,AB1252,Anti-Cytochrome P450 Enzyme CYP2E1 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H, R WB, IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1252 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cytochrome P450 Enzyme CYP2E1 Antibody Alternate Names - xenobiotic monooxygenase
- cytochrome P450 2E1
- cytochrome P450, family 2, subfamily E, polypeptide 1
- cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
- flavoprotein-linked monooxygenase
- microsomal monooxygenase
- subfamily IIE (ethanol-inducible)
- flavoprotein-linked monooxygenase
- microsomal monooxygenase
背景信息 Cytochrome P450 (CYP) is a huge and diverse superfamily of hemoproteins. It metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone.
Most CYPs can metabolize multiple substrates, and can catalyze multiple reactions. This accounts for their central importance in metabolizing the extremely large number of endogenous and exogenous molecules. In the liver, these substrates include drugs and toxic compounds as well as metabolic products such as bilirubin (a breakdown product of hemoglobin). Cytochrome P450 enzymes are present in many other tissues of the body including the mucosa of the gastrointestinal tract, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. More than 7700 distinct CYP sequences are known as of September 2007.产品信息 格式 Serum 控制 - Liver tissue.
演示 Rabbit polyclonal antiserum in buffer containing no preservative. 应用 应用 Anti-Cytochrome P450 Enzyme CYP2E1 Antibody is an antibody against Cytochrome P450 Enzyme CYP2E1 for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry:
A previous lot was used on formaldehyde treated and frozen sections.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Reacts with human and rat cytochrome P450 enzyme CYP2E1 in hepatic microsomal fractions. No cross-reactivity with other cytochrome P450 enzymes in these species. 品种反应性 MouseHumanRat Species Reactivity Note Human, mouse, and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000764
Entrez基因汇总 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. 基因符号 - CPE1
- CYP2E1
- OTTHUMP00000046571
- CYPIIE1
- CYP2E
- P450C2E
- P450-J
纯化方法 Unpurified UniProt编号 - P05181
UniProt汇总 FUNCTION: SwissProt: P05181 # Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
SIZE: 493 amino acids; 56849 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt: P05181 ## Belongs to the cytochrome P450 family.产品使用声明 质量保证 Evaluated by Western Blot on Human brain lysates.
Western Blot Analysis:
1:1000 dilution of this antibody detected Cytochrome P450 CYP2E1 on 10 μg of Human brain lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C in undiluted aliquots from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,420297,InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,14-511,Aurora A Protein, active, 10 µg
相关产品
merck millipore,默克密理博,438002,Lithium Chloride, Molecular Biology Grade - CAS 7447-41-8 - Calbiochem
merck millipore,默克密理博,DF-042-B,EmbryoMax DMEM/F12, with L-Glutamine, without HEPES
merck millipore,默克密理博,MABC677,Anti-AMACR Antibody, clone 2A10F3
merck millipore,默克密理博,ST1049,Anti-20S Proteasome α1, 2, 3, 5, 6, & 7-Subunits Mouse mAb (MCP231)
merck millipore,默克密理博,420297,InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem
merck millipore,默克密理博,14-511,Aurora A Protein, active, 10 µg
merck millipore,默克密理博,07-214,Anti-dimethyl-Histone H3 (Arg17) Antibody
merck millipore,默克密理博,529605,InSolution™ PP1 Analog - CAS 221243-82-9 - Calbiochem
merck millipore,默克密理博,AB19001,Anti-ADAM 21 Antibody, CT
merck millipore,默克密理博,05-512,Anti-TCF-3/4 Antibody, clone 6F12-3