merck millipore,默克密理愽
  • merck millipore,默克密理博,MABC677,Anti-AMACR Antibody, clone 2A10F3

  • merck millipore,默克密理博,MABC677,Anti-AMACR Antibody, clone 2A10F3

    产品名称：Anti-AMACR Antibody, clone 2A10F3
    产品型号：MABC677
    Anti-AMACR Antibody, clone 2A10F3 is a highly specific mouse monoclonal antibody, that targets AMACR & has been tested in western blotting, IHC & ICC.

    merck millipore,默克密理博,MABC677,Anti-AMACR Antibody, clone 2A10F3

  • 产品介绍
  • merck millipore,默克密理博,MABC677,Anti-AMACR Antibody, clone 2A10F3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WB, IHCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MABC677
    描述 Anti-AMACR Antibody, clone 2A10F3
    Alternate Names
    • 2-methylacyl-CoA racemase
    • Alpha-methylacyl-CoA racemase
    背景信息 Alpha-methylacyl-CoA racemase (AMACR) is an enzyme responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their S-stereoisomers. It is a racemase (RACE), which means it will catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry. AMACR is localized in peroxisomes and mitochondria. Both increases and decreases of the levels of the enzyme have been linked with human diseases. In particular, reduction in AMACR activity or protein levels leads to an increase in bile acids which can result in neurological disorders and Refsum disease, a disorder that ultimately results in cerebellar degeneration and peripheral neuropathy. AMACR deficiency also can lead to peroxisome disorders that lead to the buildup of pristanic acid, DHCA and EHCA which can lead to mental impairment, confusion, leaning difficulties and liver damage. Increased levels of AMACR are associated with prostate cancer and AMACR is widely used as a cancer marker for prostate cancer. In cancer, the protein is called P504S. Finally, AMACR is responsible for the action of ibuprofen; AMACR will convert any R-enantiomer ibuprofen to S-enantiomer, which is the bioactive form that inhibits the activity of the cyclo-oxygenase enzymes and thus bring about the anti-inflammatory effect of the drug. EMD-Millipore’s Anti-AMACR mouse monoclonal antibody, clone 2A10F3, has been tested in western blot against cell lysates from the human prostate adenocarcinoma cell line LNCaP, as well as, Jurkat cells. The clone has also been tested in immunohistochemistry in human prostate, prostate cancer, and normal cerebellum paraffin embedded tissue sections, and in fluorescent immunocytochemistry against LNCaP cells in culture.
    产品信息
    格式 Ascites
    控制
    • LNCap cell lysate
    演示 Mouse monoclonal IgG2b ascitic fluid containing up to 0.1% sodium azide.
    应用
    应用 Anti-AMACR Antibody, clone 2A10F3 is a highly specific mouse monoclonal antibody, that targets AMACR & has been tested in western blotting, IHC & ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected AMACR in human prostate cancer and human kidney tissues.

    Immunocytochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected AMACR in LNCaP cells.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Purified recombinant fragment of human AMACR expressed in E. coli.
    克隆 2A10F3
    宿主 Mouse
    同种型 IgG2b
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_055139
    基因符号
    • AMACR
    • RACE
    纯化方法 Unpurified
    UniProt编号
    • Q9UHK6
    产品使用声明
    质量保证 Evaluated by Western Blotting in LNCap cell lysate.

    Western Blotting Analysis: A 1:1,000 dilution of this antibody detected AMACR in 10 µg of LNCap cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABC677,Anti-AMACR Antibody, clone 2A10F3

上一件merck millipore产品：merck millipore,默克密理博,DF-042-B,EmbryoMax DMEM/F12, with L-Glutamine, without HEPES
下一件merck millipore产品：merck millipore,默克密理博,ST1049,Anti-20S Proteasome α1, 2, 3, 5, 6, & 7-Subunits Mouse mAb (MCP231)


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