merck millipore,默克密理愽
  • merck millipore,默克密理博,AB16969,Anti-Caspase 9 Antibody, proform & lg. subunit

  • merck millipore,默克密理博,AB16969,Anti-Caspase 9 Antibody, proform & lg. subunit

    产品名称：Anti-Caspase 9 Antibody, proform & lg. subunit
    产品型号：AB16969
    Detect Caspase 9 using this Anti-Caspase 9 Antibody, proform & lg. subunit validated for use in WB.

    merck millipore,默克密理博,AB16969,Anti-Caspase 9 Antibody, proform & lg. subunit

  • 产品介绍
  • merck millipore,默克密理博,AB16969,Anti-Caspase 9 Antibody, proform & lg. subunit

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB16969
    Replaces 04-443
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Caspase 9 Antibody, proform & lg. subunit
    Alternate Names
    • Apaf-3
    • ICE-LAP6
    • Mch-6
    产品信息
    格式 Purified
    演示 Immunoaffinity chromatography purified immunoglobulin. Liquid in PBS, containing 0.02% sodium azide.
    应用
    应用 Detect Caspase 9 using this Anti-Caspase 9 Antibody, proform & lg. subunit validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1,000 to 1:2,000

    Whole cell lysate from HeLa cells can be used as a positive control and a 46 kDa band should be detected.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids 41-56 of human caspase-9 (Duan et al. 1996; Srinivasula et al. 1996; Nijhawan et al. 1997). Recognizes proform (46 kDa); sequence analysis predicts cross-reactivity with mouse caspase-9 (>90%).
    表位 proform & lg. subunit
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3 (Duan et al. 1996; Srinivasula et al. 1996; Nijhawan et al. 1997). Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation (Nijhawan et al. 1997). Caspase-9 is also activated by granzyme B and CPP32 (Duan et al. 1996; Srinivasula et al. 1996). Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (Nijhawan et al. 1997). Caspase-9 plays a central role in cell death induced by a wide variety of apoptosis inducers including TNF-alpha, TRAIL, anti-CD-95, FADD, and TRADD (Pan et al. 1998). Caspase-9 is expressed in a variety of human tissues (Duan et al. 1996; Srinivasula et al. 1996).
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_032996.1
    • NM_001229.2
    Entrez基因汇总 This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.
    基因符号
    • Caspase-9 subunit p10].
    • CASP9
    • CASP-9
    • ICE-LAP6
    • APAF3
    • MCH6
    • CASPASE-9c
    • OTTHUMP00000044594
    • APAF-3
    • EC 3.4.22.62 [Contains: Caspase-9 subunit p35
    非反应性品种
    • Rat
    UniProt编号
    • P55211
    UniProt汇总 FUNCTION: SwissProt: P55211 # Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
    SIZE: 416 amino acids; 46281 Da
    SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts with the inhibitors BIRC2, BIRC4, BIRC5 and BIRC7.
    TISSUE SPECIFICITY: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues.
    PTM: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase- 3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
    SIMILARITY: SwissProt: P55211 ## Belongs to the peptidase C14 family. & Contains 1 CARD domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The undiluted antibody solution is stable for approximately 6 months when stored 2-8°C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB16969,Anti-Caspase 9 Antibody, proform & lg. subunit

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