merck millipore,默克密理愽
  • merck millipore,默克密理博,124028,Akt Inhibitor XI - Calbiochem

  • merck millipore,默克密理博,124028,Akt Inhibitor XI - Calbiochem

    产品名称：Akt Inhibitor XI - Calbiochem
    产品型号：124028
    The Akt Inhibitor XI controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,124028,Akt Inhibitor XI - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,124028,Akt Inhibitor XI - Calbiochem

    重要规格表

    经验配方
    C₁₁H₉Cl₂CuN₃O₂S
    描述
    概述 A cell-permeable copper complex (Cu2+/Cu+ redox couple in the range of +0.28 to +0.35 V) that interacts with both the PH and the kinase domains of Akt and potently inhibits its kinase activity (IC50 = 100 nM). Inhibits tumor growth both in cultured cells in vitro (IC50 ranges from 10 to 34 µM) and in mice in vivo (25 mg/kg, iv) without any apparent adverse effect to the animals.
    产品目录编号 124028
    品牌系列 Calbiochem®
    同义词 3-Formylchromone thiosemicarbazone, Cu(II)Cl₂ Complex, FPA-124
    参考
    参考 Barve, V., et al. 2006. J. Med. Chem. 49, 3800.
    产品信息
    具有ATP竞争性 N
    形式 Green solid
    Hill配方 C₁₁H₉Cl₂CuN₃O₂S
    化学配方 C₁₁H₉Cl₂CuN₃O₂S
    Molar Mass 381.7
    可逆 N
    结构配方图像
    生物信息
    主靶 Akt
    主靶IC50 100 nM against Akt
    纯度 ≥98% by Elemental Analysis
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,124028,Akt Inhibitor XI - Calbiochem

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