merck millipore,默克密理博,AB16943,Anti-DcR2 Antibody, intracellular domain

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merck millipore,默克密理博,AB16943,Anti-DcR2 Antibody, intracellular domain
产品名称：Anti-DcR2 Antibody, intracellular domain
产品型号：AB16943
Anti-DcR2 Antibody, intracellular domain detects level of DcR2 & has been published & validated for use in WB, IH.

merck millipore,默克密理博,AB16943,Anti-DcR2 Antibody, intracellular domain

产品介绍

merck millipore,默克密理博,AB16943,Anti-DcR2 Antibody, intracellular domain

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	AB16943
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-DcR2 Antibody, intracellular domain
Alternate Names	TRUNDD TRAIL-R4

产品信息
格式	Purified
演示	Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

应用
应用	Anti-DcR2 Antibody, intracellular domain detects level of DcR2 & has been published & validated for use in WB, IH.
主要应用	Immunohistochemistry Western Blotting
应用说明	Western blot: 1:100 to 1:4000 Immunohistochemistry: 10 µg/mL Whole cell lysate from HeLa cells can be used as a positive control . Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Polyclonal antibody raised against a peptide corresponding to amino acids 249-263 of human DcR2 precursor (Marsters et al. 1997; Degli-Esposti et al. 1997; Pan et al. 1997).
表位	intracellular domain
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (Pan et al. 1997a,b; Sheridan et al. 1997). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (Marsters et al. 1997; Degli-Esposti et al. 1997; Pan et al. 1997). DcR2 has an extracellular TRAIL binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.
品种反应性	Human
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_003840.3
Entrez基因汇总	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.
基因符号	DCR2 TNFRSF10D CD264 DcR2 TRUNDD TRAIL-R4 TRAILR4
UniProt编号	Q9UBN6
UniProt汇总	FUNCTION: SwissProt: Q9UBN6 # Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway (According to PubMed:9382840 it cannot but according to PubMed:9430226 it can induce the NF-kappa-B pathway). SIZE: 386 amino acids; 41823 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. SIMILARITY: SwissProt: Q9UBN6 ## Contains 1 death domain. & Contains 3 TNFR-Cys repeats.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

包装信息
数量	100 µg

merck millipore,默克密理博,AB16943,Anti-DcR2 Antibody, intracellular domain

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