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merck millipore,默克密理博,MABE72,Anti-Ash2 Antibody, clone 7E1
产品名称：Anti-Ash2 Antibody, clone 7E1
产品型号：MABE72
Anti-Ash2 Antibody, clone 7E1 is a Rat Monoclonal Antibody for detection of Ash2 also known as Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2-like protein & has been validated in WB, I More>>
merck millipore,默克密理博,MABE72,Anti-Ash2 Antibody, clone 7E1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB R Purified Monoclonal Antibody 描述 产品目录编号 MABE72 描述 Anti-Ash2 Antibody, clone 7E1 Alternate Names - Set1/Ash2 histone methyltransferase complex subunit ASH2: ASH2-like protein
背景信息 Ash2 (absent, small or homeotic discs2) is a trithorax protein that as part of a complex trimethylates histone H3 at lysine 4. The resulting histone mark is associated with actively transcribed genes. Ash2 has been implicated as an oncoprotein and may function as a transcriptional regulator. .As a component of the Set1/Ash2 histone methyltransferase (HMT) complex, this complex specifically methylates lysine 4 of histone H3, unless the neighboring lysine 9 residue is already methylated. ASH2L is also a component of MLL-containing complexes. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. Ash2 has been shown to play a role in hematopoiesis and is associated with some special kinds of leukemia. The amount of ASH2L transcripts is extremely high in fetal liver, testis, and leukemia cell lines with erythroid and megakaryocytic potential 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl without 0.05% sodium azide. 应用 应用 Anti-Ash2 Antibody, clone 7E1 is a Rat Monoclonal Antibody for detection of Ash2 also known as Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2-like protein & has been validated in WB, IP & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human Ash2. 克隆 7E1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001098684
基因符号 - ASH2L:ASH2L1
纯化方法 Protein G UniProt编号 - Q9UBL3
UniProt汇总 FUNCTION: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.
SUBUNIT STRUCTURE: Interacts with HCFC1. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, IN80C, KDM6A, KIAA1267, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with DPY30 and RBBP5; the interaction is direct.
SUBCELLULAR LOCATION: Nucleus Probable
TISSUE SPECIFICITY: Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. Ref.2
SEQUENCE SIMILARITIES: Contains 1 B30.2/SPRY domain.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Ash2 on 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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