merck millipore,默克密理博,14-750,Abl (H396P) Protein, active, 10 µg

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Merck Millipore 默克密理愽

描述
产品目录编号	14-750
品牌系列	Upstate
商名	Upstate
描述	Abl (H396P) Protein, active, 10 µg
概述	The Abl tyrosine kinase inhibitor STI571 (Gleevec™) is an effective therapy for stable-phase chronic myeloid leukemia patients. Many patients responding to STI571 later relapse, due to a reactivation of Bcr-Abl activity. In certain cases this appears to correlate with the presence of the H396P mutation, which confers resistance to drug binding due to steric interference. (Corbin AS. et al, Blood, (2002); 101:4611-4614 and La Rosee P. et al, Cancer Research; 62:7149-7153).

产品信息
演示	50mM Tris/HCl pH7.5, 150mM NaCl, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij 35. Frozen solution.

应用
应用	Active, N-terminal 6His-tagged recombinant human Abl, residues 27-end containing the H396P mutation. Expressed by baculovirus in Sf21 insect cells. For use in Kinase Assays.
主要应用	Kinase Assay

生物信息
来源	N-terminal 6His-tagged recombinant human Abl, residues 27-end containing the H396P mutation. Expressed by baculovirus in Sf21 insect cells.
品种	Human
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez基因编号	U07563
基因符号	bcr/abl ABL1 JTK7 ABL p150 vABL cABL
蛋白靶	Abl
纯化方法	Ni²⁺/NTA-agarose
靶子系列	TK
UniProt编号	P00519

产品使用声明
质量保证	Routinely evaluated by phosphorylation of Abltide.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap. Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.

包装信息
数量	10 µg
包装	Also available in 250μg size as catalog # 14-750M - Call for pricing and availability.

merck millipore,默克密理博,14-750,Abl (H396P) Protein, active, 10 µg

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