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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-217 品牌系列 Upstate
商名 - Upstate
描述 Anti-Raptor Antibody Alternate Names - regulatory associated protein of mTOR
- p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
产品信息 格式 Affinity Purified 演示 Affinity purified rabbit polyclonal IgG in 0.02M PBS, 0.25M sodium chloride containing 0.1% sodium azide and 50% glycerol. 应用 应用 Detect Raptor using this anti-Raptor Antibody validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH conjugated peptide encompassing the N-terminal region of human Raptor. 宿主 Rabbit 同种型 IgG 品种反应性 Human Species Reactivity Note Other species have not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_020761.2
基因符号 - Raptor
- KIAA1303
纯化方法 Immunoaffinity purified UniProt编号 - Q8N122
UniProt汇总 FUNCTION: SwissProt: Q8N122 # Participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). Plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. Has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.
SIZE: 1335 amino acids; 149038 Da
SUBUNIT: Binds directly 4EBP1 and RPS6KB1 independently of its association with FRAP1. Binds preferentially to poorly or non- phosphorylated form of EIF4EBP1, and this binding is critical to the ability of FRAP1 to catalyze phosphorylation. Complex with FRAP1 physically interacts under both leucine-rich and -poor conditions and therefore in at least two nutrient-determined states with different stability.
TISSUE SPECIFICITY: Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta.
SIMILARITY: SwissProt: Q8N122 ## Contains 7 WD repeats.
MISCELLANEOUS: Rapamycin destabilizes the interaction with FRAP1 regardless of nutrient availability, and its potency for dissociation is increased under nutrient-rich conditions. This action uncouples FRAP1 from its substrates, and inhibits FRAP1 signaling without altering its intrinsic catalytic activity.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µL
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