merck millipore,默克密理愽
  • merck millipore,默克密理博,07-517,Anti-Ran Antibody

  • merck millipore,默克密理博,07-517,Anti-Ran Antibody

    产品名称：Anti-Ran Antibody
    产品型号：07-517
    Anti-Ran Antibody detects level of Ran & has been published & validated for use in IP, WB & IC.

    merck millipore,默克密理博,07-517,Anti-Ran Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-517,Anti-Ran Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Xn, HICC, WBRbSerumPolyclonal Antibody
    描述
    产品目录编号 07-517
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Ran Antibody
    产品信息
    格式 Serum
    演示 PBS and 0.1% sodium azide.
    应用
    应用 Anti-Ran Antibody detects level of Ran & has been published & validated for use in IP, WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 His-tagged recombinant human Ran protein purified from E. coli.
    宿主 Rabbit
    特异性 Ran
    同种型 IgG
    品种反应性 XenopusHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_006325
    Entrez基因汇总 RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
    基因符号
    • RANBP3
    • RAN
    • Gsp1
    • ARA24
    • OK/SW-cl.81
    • TC4
    纯化方法 Antiserum
    UniProt编号
    • P62826
    UniProt汇总 FUNCTION: SwissProt: P62826 # Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
    SIZE: 216 amino acids; 24423 Da
    SUBUNIT: Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1.
    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Melanosome. Note=Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    TISSUE SPECIFICITY: Expressed in a variety of tissues.
    PTM: The N-terminus is blocked.
    SIMILARITY: SwissProt: P62826 ## Belongs to the small GTPase superfamily. Ran family.
    产品使用声明
    质量保证 routinely evaluated by immunoblot in RIPA lysates from HeLa cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-517,Anti-Ran Antibody

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