merck millipore,默克密理愽
  • merck millipore,默克密理博,444144,MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem

  • merck millipore,默克密理博,444144,MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem

    产品名称：MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem
    产品型号：444144
    The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.

    merck millipore,默克密理博,444144,MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444144,MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₂₀N₂O6964-62-1
    描述
    概述 A cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
    产品目录编号 444144
    品牌系列 Calbiochem®
    同义词 7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II
    参考
    参考 Lu, Y., et al. 2006. J. Med. Chem. 49, 3759.
    产品信息
    CAS号 6964-62-1
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₃H₂₀N₂O
    化学配方 C₂₃H₂₀N₂O
    Molar Mass 340.4
    可逆 N
    结构配方图像
    生物信息
    主靶 MDM2
    主靶Ki 120 nM against MDM2
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444144,MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem

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