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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15582 Replaces AB5696 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-ASH1 Antibody Alternate Names - ASH-1
- MASH1
- KMT2H
- Mammalian Achaete-scute homolog 1
- Class A basic helix-loop-helix protein 46
产品信息 格式 Affinity Purified 演示 Liquid in PBS with 0.1% sodium azide. 应用 应用 Anti-ASH1 Antibody detects level of ASH1 & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 0.5-1.0 μg/mL on mouse hippocampus lysate.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 ASH1 (MASH1, mammalian achaete-scute homolog 1). By Western blot the antibody recognizes a band at ~30 kDa on mouse hippocampus lysate. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004307
Entrez基因汇总 This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests that it may also play a role in tumor formation. 基因符号 - ASH1
- ASCL1
- HASH1
- MASH1
纯化方法 Immunoaffinity purified UniProt编号 - P50553
UniProt汇总 FUNCTION: SwissProt: P50553 # May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Activates transcription by binding to the E box (5'-CANNTG-3').
SIZE: 236 amino acids; 25454 Da
SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: SwissProt: P50553 ## Contains 1 basic helix-loop-helix (bHLH) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. 包装信息 数量 100 µg
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