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经验配方 CAS号 C₈H₁₀FNO₂S · HCl 30827-99-7 描述 概述 Specific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436). 产品目录编号 101500 品牌系列 Calbiochem®
同义词 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl 应用数据 
参考 参考 Citron, M., et al. 1996. Neuron 17, 171.
Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
Mintz, G.R. 1993. BioPharm. 6, 34.
Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.产品信息 CAS号 30827-99-7 具有ATP竞争性 N 形式 White to off-white solid Hill配方 C₈H₁₀FNO₂S · HCl 化学配方 C₈H₁₀FNO₂S · HCl Molar Mass 239.7 可逆 N 结构配方图像 生物信息 主靶 chymotrypsin 纯度 >97% by HPLC 理化信息 细胞可渗透 N 溶解度 H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +15°C to +30°C
防潮 Protect from moisture
无需冷冻 No
特殊指南 Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9). 包装信息 惰性气体下包装 Packaged under inert gas
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