merck millipore,默克密理愽
  • merck millipore,默克密理博,AB15325,Anti-Nicotinic Acetylcholine Receptor β2 Antibody

  • merck millipore,默克密理博,AB15325,Anti-Nicotinic Acetylcholine Receptor β2 Antibody

    产品名称：Anti-Nicotinic Acetylcholine Receptor β2 Antibody
    产品型号：AB15325
    Detect Nicotinic Acetylcholine Receptor β2 using this Anti-Nicotinic Acetylcholine Receptor β2 Antibody validated for use in WB.

    merck millipore,默克密理博,AB15325,Anti-Nicotinic Acetylcholine Receptor β2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB15325,Anti-Nicotinic Acetylcholine Receptor β2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, M, RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB15325
    描述 Anti-Nicotinic Acetylcholine Receptor β2 Antibody
    Alternate Names
    • neuronal nicotinic acetylcholine receptor beta 2
    • cholinergic receptor, nicotinic, beta 2 (neuronal)
    • cholinergic receptor, nicotinic, beta polypeptide 2<br />(neuronal)
    背景信息 Nicotinic acetylcholine receptors, also known as nAChRs, belong to a family of proteins called ligand gated ion channels and are widely expressed throughout the nervous system. nAChRs are made up of 5 subunits (two α and three β). Subunits α4 and β2 (α4β2) is the main receptor in the mammalian brain and has been associated with the positive reinforcing effects of nicotine. The relative contribution of nAChRs β2 and β4 are not well understood because the subunit structure that mediates synaptic transmission in the peripheral nervous system is unknown.
    产品信息
    格式 Affinity Purified
    控制
    • Rat e16 brain lysate
    演示 Rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Nicotinic Acetylcholine Receptor β2 using this Anti-Nicotinic Acetylcholine Receptor β2 Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 This antibody is generated from rabbits immunized with a KLH-conjugated linear peptide selected from residues of Nicotinic Acetylcholine Receptor β2.
    表位 Extracellular Domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Nicotinic Acetylcholine Receptor β2.
    品种反应性 HumanMouseRat
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_062170
    Entrez基因汇总 Co-assembles with the alpha 7 subunit to form a functional heteromeric nicotinic acetylcholine receptor [RGD].
    基因符号
    • nAChRB2
    • EFNL3
    • OTTHUMP00000035374
    修改
    • Acetylation
    纯化方法 Affinity Purfied
    UniProt编号
    • P17787
    UniProt汇总 FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    SUBUNIT STRUCTURE: Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.
    SUBCELLULAR LOCATION: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
    INVOLVEMENT IN DISEASE: Defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3) [MIM:605375]. ENFL3 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
    SEQUENCE SIMILARITIES: Belongs to the ligand-gated ionic channel (TC 1.A.9) family. [View classification]
    产品使用声明
    质量保证 Routinely evaluated by Western Blot in rat e16 brain lysate.
    Western Blot Analysis: : 1:20,000 dilution of this lot detected Nicotinic Acetylcholine Receptor β2 on 10 µg of rat e16 brain lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB15325,Anti-Nicotinic Acetylcholine Receptor β2 Antibody

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