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品种反应性 主要应用 宿主 格式 抗体类型 M WB, ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 AB15520 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Neuronal pentraxin 2 Antibody Alternate Names - NPX2
背景信息 Neuronal Pentraxins: A new family of putative integral membrane pentraxins or Neuronal pentraxins identified through interaction with a presynaptic snake venom toxin taipoxin. NPX1, NPX2 and NPXR (Neuronal Pentraxin Receptor), the three neuronal pentraxins represent a novel neuronal uptake pathway that may function during synapse formation and remodeling. The N-terminal half of neuronal pentraxins are 20-30% identical to previously identified pentraxins (CRP and SAP), the three neuronal pentraxins are 50% identical to each other and are significantly larger than the classical pentraxins (>50 versus 30kDa), suggesting that they may have additional novel functions. NPX2 (Neuronal Pentraxin 2), 429aa in mouse, 432 in rat and 431 in human (chr 7q21), mainly expressed in brain, pancrease, liver and testis. It is likely to play role in the modification of cellular properties that underlie long-term plasticity. NPX1, NPX2 has potential N-linked glycosylation sites. 产品信息 格式 Purified 演示 Liquid in 100 mM Tris, pH 7.5, with 0.2% BSA and 0.05% sodium azide. 应用 应用 Detect Neuronal pentraxin 2 using this Anti-Neuronal pentraxin 2 Antibody validated for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-10 µg/mL using ECL.
Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL
ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide near the N-terminus of mouse NPX2 宿主 Rabbit 品种反应性 Mouse Species Reactivity Note Other species have not yet been tested. The immunogen sequence is 100% conserved in rat, and 94% in human NPX2 and 82% in guinea pig apexin precursor P50. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002523.1
基因符号 - NARP
- NPTX2
- NP-II
- NP2
纯化方法 Immunoaffinity purified UniProt编号 - P47972
UniProt汇总 FUNCTION: SwissProt: P47972 # Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).
COFACTOR: Binds 2 calcium ions per subunit (By similarity).
SIZE: 431 amino acids; 47042 Da
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.
SIMILARITY: SwissProt: P47972 ## Contains 1 pentaxin domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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