merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1920,Anti-Laminin γ1 Antibody, clone 2E8

  • merck millipore,默克密理博,MAB1920,Anti-Laminin γ1 Antibody, clone 2E8

    产品名称：Anti-Laminin γ1 Antibody, clone 2E8
    产品型号：MAB1920
    This Anti-Laminin γ1 Antibody, clone 2E8 is validated for use in ELISA, CULT, IH, IP, WB for the detection of Laminin γ1.

    merck millipore,默克密理博,MAB1920,Anti-Laminin γ1 Antibody, clone 2E8

  • 产品介绍
  • merck millipore,默克密理博,MAB1920,Anti-Laminin γ1 Antibody, clone 2E8

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWB, ELISA, CULT, IHCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB1920
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Laminin γ1 Antibody, clone 2E8
    Alternate Names
    • Laminin B2 Chain
    产品信息
    格式 Ascites
    控制
    • Basement membrane, Hippocampal tissue
    演示 Liquid, no preservatives added.
    应用
    应用 This Anti-Laminin γ1 Antibody, clone 2E8 is validated for use in ELISA, CULT, IH, IP, WB for the detection of Laminin γ1.
    主要应用
    • Western Blotting
    • ELISA
    • Cell Culture
    • Immunohistochemistry
    应用说明 ELISA (50% maximal binding to human laminin): (1:300,000.

    Immunofluorescence

    Affinity chromatography

    Immunoprecipitation

    Immunoblotting

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Purified human laminin
    克隆 2E8
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with the B2 chain of intact human laminin and does not block the neurite stimulating activity of laminin. Cross reacts with the 200 kDa chain of rat laminin.
    同种型 IgG1κ
    品种反应性 RatHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002293.3
    Entrez基因汇总 Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.
    基因符号
    • MGC87297
    • LAMC1
    • LAMB2
    纯化方法 Unpurified
    UniProt编号
    • P11047
    UniProt汇总 FUNCTION: SwissProt: P11047 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
    SIZE: 1609 amino acids; 177607 Da
    SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (EHS laminin), laminin-2 (merosin), laminin-3 (S-laminin), laminin-4 (S-merosin), laminin-6 (K-laminin) and laminin-7 (KS-laminin).
    SUBCELLULAR LOCATION: Secreted, extracellular space.
    TISSUE SPECIFICITY: Found in the basement membranes (major component).
    DOMAIN: SwissProt: P11047 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domains VI and IV are globular.
    SIMILARITY: Contains 11 laminin EGF-like domains. & Contains 1 laminin IV type A domain. & Contains 1 laminin N-terminal domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB1920,Anti-Laminin γ1 Antibody, clone 2E8

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