merck millipore,默克密理愽
  • merck millipore,默克密理博,676492,VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

  • merck millipore,默克密理博,676492,VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

    产品名称：VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem
    产品型号：676492
    The VEGFR3 Kinase Inhibitor, MAZ51, also referenced under CAS 163655-37-6, controls the biological activity of VEGFR3 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Deph More>>

    merck millipore,默克密理博,676492,VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,676492,VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₁₈N₂O163655-37-6
    描述
    概述 A cell-permeable 3-substituted indolin-2-one compound that acts as a reversible and ATP-competitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 µM), it specifically blocks VEGF-C- (Cat. No. 676476) and VEGF-D- (Cat. No. 676471) induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis. Not available for sale in Germany.
    产品目录编号 676492
    品牌系列 Calbiochem®
    同义词 MAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
    参考
    参考 Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
    产品信息
    CAS号 163655-37-6
    具有ATP竞争性 Y
    声明 Not available for sale in Germany.
    形式 Red solid
    Hill配方 C₂₁H₁₈N₂O
    化学配方 C₂₁H₁₈N₂O
    Molar Mass 314.1
    可逆 Y
    结构配方图像
    生物信息
    主靶 VEGF receptor tyrosine kinase
    主靶IC50 At low concentration (≤5 µM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells.
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,676492,VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

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