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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB, ICC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB15404 Replaces MABC137 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-APG5 Antibody Alternate Names - Autophagy-related protein 5, APG5-like, ATG5, Apoptosis-specific protein
- Autophagy-related protein 5
- APG5-like
- ATG5
背景信息 Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. APG5 conjugates to APG12 and this conjugate is required for elongation of the isolation membrane to form a complete spherical autophagosome. The APG5 protein may play an important role in the apoptotic process, possibly within the modified cytoskeleton. 产品信息 格式 Serum 演示 Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative. 应用 应用 This Anti-APG5 Antibody is validated for use in WB, IC, IH for the detection of APG5. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western blot: 1:200-1:1,000
Immunocytochemistry: 1:200-1:1,000
Immunohistochemistry: 1:200-1:1,000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to a region within the C-terminus of human APG5 protein. 宿主 Rabbit 特异性 APG5 [Autophagy-related protein 5, APG5-like, ATG5, Apoptosis-specific protein]. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004849.2
基因符号 - hAPG5
- ATG5
- ASP
- APG5-like
- APG5
- OTTHUMP00000040507
- APG5L
纯化方法 Serum UniProt编号 - Q9H1Y0
UniProt汇总 FUNCTION: SwissProt: Q9H1Y0 # May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
SIZE: 275 amino acids; 32447 Da
SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with nonmuscle actin.
TISSUE SPECIFICITY: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
SIMILARITY: SwissProt: Q9H1Y0 ## Belongs to the ATG5 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability. 包装信息 数量 50 µL
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