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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB3875 Replaces 04-453 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-SUMO1 Antibody Alternate Names - Sentrin
- Small Ubiquitin-like Modifier
- SMT3C
产品信息 格式 Purified 演示 Immunoglobulin was purified by protein G affinity chromatography and is presented as a liquid in PBS with 0.09% sodium azide. 应用 应用 Detect SUMO1 using this Anti-SUMO1 Antibody validated for use in ELISA, WB, IH. 主要应用 - Immunohistochemistry
- ELISA
- Western Blotting
应用说明 Western blot: 1:500. (12kDa)
ELISA: 1:1000
Immunohistochemistry: 1:50-1:100
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to the N-terminal region of human SUMO1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes human SUMO1 (small ubiquitin-like modifier), also known as Sentrin. SUMO has been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS, and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. These bindings implicate SUMO in the stabilization of the target proteins and/or their localization to subcellular complexes. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003352.4
- NM_001005781.1
- NM_001005782.1
Entrez基因汇总 This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. 基因符号 - SMT3C
- SUMO1
- Sentrin
- OFC10
- UBL1
- SENP2
- DAP-1
- sentrin
- SMT3H3
- SMT3
- PIC1
- SUMO-1
- GMP1
UniProt编号 - P63165
UniProt汇总 FUNCTION: SwissProt: P63165 # Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1- SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.
SIZE: 101 amino acids; 11557 Da
SUBUNIT: Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52.
SUBCELLULAR LOCATION: Nucleus membrane. Nucleus speckle. Cytoplasm.
PTM: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
SIMILARITY: SwissProt: P63165 ## Belongs to the ubiquitin family. SUMO subfamily. & Contains 1 ubiquitin-like domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20ºC in undiluted aliquots for up to one year from date of receipt. 包装信息 数量 100 µg
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