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merck millipore,默克密理博,05-1214,Anti-FXR2 Antibody, clone 2C8.2
产品名称：Anti-FXR2 Antibody, clone 2C8.2
产品型号：05-1214
Anti-FXR2 Antibody, clone 2C8.2 is a Mouse Monoclonal Antibody for detection of FXR2 also known as Fragile X mental retardation syndrome-related protein 2 & has been validated in WB, ICC.
merck millipore,默克密理博,05-1214,Anti-FXR2 Antibody, clone 2C8.2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H, R ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1214 描述 Anti-FXR2 Antibody, clone 2C8.2 Alternate Names - Fragile X mental retardation syndrome-related protein 2
背景信息 Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA-binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding. FXR2 is very similar to FMR1 (60% identity). FXR2 encodes a 74 kDa protein which, like FMR1, contains two KH domains, has the capacity to bind RNA and is localized to the cytoplasm. The FXR2 gene is located on human chromosome 17 at 17p13.1. In addition, FMR1 and FXR2 interact tightly with the recently described autosomal homolog FXR1. Each of these three proteins is capable of forming heterodimers with the others, and each can also form homodimers. FXR1 and FXR2 are thus likely to play important roles in the function of FMR1 and in the pathogenesis of the Fragile X Mental Retardation Syndrome. 产品信息 格式 Purified 控制 - HEK293 cell lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-FXR2 Antibody, clone 2C8.2 is a Mouse Monoclonal Antibody for detection of FXR2 also known as Fragile X mental retardation syndrome-related protein 2 & has been validated in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FXR2 in A431 cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human FXR2. 克隆 2C8.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 MouseHumanRat Species Reactivity Note Demonstrated to react with Human, Rat, and Mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_004851
Entrez基因汇总 The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. [provided by RefSeq]. 基因符号 - FMR1L2
- FXR2
纯化方法 Protein G UniProt编号 - P51116
UniProt汇总 FUNCTION: RNA-binding protein.
SUBUNIT STRUCTURE: Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3. Ref.9
SUBCELLULAR LOCATION: Cytoplasm.
SEQUENCE SIMILARITIES: Belongs to the FMR1 family.
Contains 2 KH domains.产品使用声明 质量保证 Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected FXR2 on 10 µg of HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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