• merck millipore,默克密理博,AB986,Anti-β Galactosidase Antibody, bacterial
  • merck millipore,默克密理博,AB986,Anti-β Galactosidase Antibody, bacterial

    产品名称:Anti-β Galactosidase Antibody, bacterial
    产品型号:AB986
    Anti-β Galactosidase Antibody, bacterial detects level of β Galactosidase & has been published & validated for use in ELISA, IP, WB, IH.

    merck millipore,默克密理博,AB986,Anti-β Galactosidase Antibody, bacterial

  • 产品介绍
  • merck millipore,默克密理博,AB986,Anti-β Galactosidase Antibody, bacterial

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    E. coli, VrtIHC, ELISA, WBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB986
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-β Galactosidase Antibody, bacterial
    产品信息
    格式 Serum
    演示 Rabbit antisera prepared by delipidation and defibrination. Lyophilized. Reconstitute with 2 mL of sterile deionized water. Contains 0.02M Potassium Phosphate, 0.15M NaCl and 0.01% sodium azide after reconstitution.
    应用
    应用 Anti-β Galactosidase Antibody, bacterial detects level of β Galactosidase & has been published & validated for use in ELISA, IP, WB, IH.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Western Blotting
    应用说明 Immunoblotting: 1:500-1:2,000

    Immunoprecipitation

    Immunohistochemistry (Zhang, 2002)

    ELISA: 1:2,000-1:10,000 when tested against 1 μg of immunogen by a standard sandwich ELISA.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Beta galactosidase from E-coli.
    表位 bacterial
    宿主 Rabbit
    特异性 Specific for Beta galactosidase from E coli by IEP. May cross react with Beta galactosidase from other species.
    品种反应性 E. coliVertebrates
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001079811.1
    • NM_000404.2
    Entrez基因汇总 The GLB1 gene encodes beta-galactosidase-1 (EC 3.2.1.23), a lysosomal hydrolase that cleaves the terminal beta-galactose from ganglioside substrates and other glycoconjugates (Yoshida et al., 1991 [PubMed 1907800]). Beta-galactosidase also occurs in a complex with neuraminidase (NEU1; MIM 608272) and protective protein/cathepsin A (PPCA; MIM 256540), which is a component of certain cell surface receptors (Hinek, 1996 [PubMed 8922281]). See also galactosylceramidase (GALC; MIM 606890) (EC 3.2.1.46), a genetically distinct beta-galactosidase that is involved in the catabolism of other lipid compounds.[supplied by OMIM]
    基因符号
    • EC 3.2.1.23
    • GLB1
    • Lactase
    • S-Gal
    • ELNR1
    • EBP
    UniProt编号
    • P16279
    UniProt汇总 FUNCTION: SwissProt: P16279 # This protein has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non- integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.| P16278 # Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
    SIZE: 546 amino acids; 60552 Da
    SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Note=Localized to the perinuclear area of the cytoplasm but not to lysosomes.
    DOMAIN: SwissProt: P16279
    DISEASE: SwissProt: P16278 # Defects in GLB1 are the cause of GM1-gangliosidosis type I [MIM:230500]; also known as infantile GM1-gangliosidosis. This autosomal recessive disorder is characterized by the accumulation in visceral tissues, and ultimately excessive excretion in the urine, of beta-linked galactose-terminal oligosaccharides. Patients show central nervous system degeneration, and the coarse facial features, hepatosplenomegaly and skeletal dysmorphology reminiscent of Hurler syndrome. The infantile form is rapidly progressive leading to death usually between the first and second year. & Defects in GLB1 are the cause of GM1-gangliosidosis type II [MIM:230600]; also known as late infantile/juvenile type GM1- gangliosidosis. Patients do not display the skeletal changes associated with the infantile form, but they nonetheless excrete elevated amounts of beta-linked galactose-terminal oligosaccharides. Inheritance is autosomal recessive. & Defects in GLB1 are the cause of GM1-gangliosidosis type III [MIM:230650]; also known as adult or chronic GM1- gangliosidosis. Patients show mild skeletal abnormalities, dysarthria, gait disturbance, dystonia and visual impairment. Visceromegaly is absent. Inheritance is autosomal recessive. & Defects in GLB1 are the cause of mucopolysaccharidosis IV B (MPS4B) [MIM:253010]; also known as Morquio syndrome B. MPS4B is a rare autosomal recessive disorder characterized by severe bone deformities without CNS involvement.
    SIMILARITY: SwissProt: P16279 ## Belongs to the glycosyl hydrolase 35 family. | P16278 ## Belongs to the glycosyl hydrolase 35 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at 2-8°C for up to 12 months. After reconstitution maintain in undiluted aliquots at -20°C for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 2 mL

    merck millipore,默克密理博,AB986,Anti-β Galactosidase Antibody, bacterial

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