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  • merck millipore,默克密理博,AB144,Anti-Choline Acetyltransferase Antibody

  • merck millipore,默克密理博,AB144,Anti-Choline Acetyltransferase Antibody

    产品名称：Anti-Choline Acetyltransferase Antibody
    产品型号：AB144
    Anti-Choline Acetyltransferase Antibody is an antibody against Choline Acetyltransferase for use in IH & WB.

    merck millipore,默克密理博,AB144,Anti-Choline Acetyltransferase Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB144,Anti-Choline Acetyltransferase Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, Gp, MWB, IHCGtSerumPolyclonal Antibody
    描述
    产品目录编号 AB144
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Choline Acetyltransferase Antibody
    Alternate Names
    • ChAT
    背景信息 Acetylcholine (ACh) is a common neurotransmitter for motoneurons, preganglionic autonomic neurons, postganglionic parasympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-cholinacetyltransferase a useful specific marker.
    产品信息
    格式 Serum
    控制
    • Rat brain tissue
    演示 Goat antisera, liquid, no preservatives.
    应用
    应用 Anti-Choline Acetyltransferase Antibody is an antibody against Choline Acetyltransferase for use in IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunoblot: 1:1,000-1:5,000

    Immunohistochemistry: 1:500-1:1,000. See page two of this data sheet.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Human placental enzyme.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Goat
    特异性 Recognizes cholinergic neurons in brain and central nervous systems.
    品种反应性 RatGuinea PigMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_020986.2
    • NM_020549.3
    • NM_020984.2
    • NM_020985.2
    Entrez基因汇总 Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.
    基因符号
    • CMS1A2
    • CHAT
    • ChAT
    • CHOACTase
    • CMS1A
    纯化方法 Unpurified
    UniProt编号
    • P28329
    UniProt汇总 FUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
    SIZE: 748 amino acids; 82568 Da
    DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.
    SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB144,Anti-Choline Acetyltransferase Antibody

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